Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
View Patent ↗The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof, wherein said dual serotonin norepinephrine reuptake inhibitor compound is characterized by a non-tricyclic structure and an equal or greater inhibition of norepinephrine reuptake than serotonin reuptake. In particular, the use of milnacipran to treat FMS, CFS, and pain is disclosed.
1. A method of treating pain in an animal subject, comprising administering to an animal subject suffering from pain, an effective amount of milnacipran, or a pharmaceutically acceptable salt thereof, alone or in combination with a compound that is not phenylalanine, tyrosine or tryptophan.
2. The method according to claim 1 , wherein the compound is adjunctively administered with antidepressants, analgesics, muscle relaxants, anorectics, stimulants, antiepileptic drugs, sedatives, or hypnotics.
3. The method according to claim 1 , wherein the compound is adjunctively administered with neurontin, pregabalin, pramipexole, 1-DOPA, amphetamine, tizanidine, clonidine, tramadol, morphine, a tricyclic antidepressant, codeine, carbamazepine, sibutramine, valium, or trazodone.
4. The method according to claim 1 , wherein the animal subject is human.
5. The method according to claim 1 , wherein the amount administered is from about 25 mg to about 400 mg per day.
6. The method according to claim 1 , wherein the compound is formulated in a sustained release dosage formulation.