Devices and methods for treating defects in the tissue of a living being
View Patent ↗An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
1. An implant for the repair or regeneration of bone tissue of a living being, said implant comprising a porous osteoconductive matrix and a depot of material, at least a portion of said matrix comprising soluble collagen and native insoluble collagen, wherein said native insoluble collagen comprises native collagen fibers, and wherein said at least a portion of said matrix defines pores of a diameter of greater than about 100 microns, and still further wherein said implant is arranged to be implanted within a body of a living being.
2. The implant of claim 1 , wherein said depot of material further comprises at least one therapy.
3. The implant of claim 2 , wherein said therapy comprises at least one of blood cells, drugs and biologically active agents.
4. The implant of claim 1 , wherein said matrix further comprises at least one therapy.
5. The implant of claim 4 , wherein said therapy comprises at least one of drugs and biologically active agents.
6. The implant of claim 1 , wherein said matrix comprises at least one polymer in addition to said soluble collagen and native insoluble collagen.
7. The implant of claim 6 , wherein said additional polymer is at least partially bio-resorbable.
8. The implant of claim 7 , wherein said additional polymer comprises at least one of chitin, PGA/PLLA copolymers, hydrogel, Lactide/ε-caprolactone copolymers, PGA, PLA, and PCL.
9. The implant of claim 6 , wherein said additional polymer is not cross-linked.
10. The implant of claim 1 , wherein said matrix is capable of functioning as a carrier for material lacking structural competence.
11. The implant of claim 10 , wherein said material lacking structural competence comprises at least one ceramic.
12. The implant of claim 11 , wherein said ceramic comprises calcium salt.
13. The implant of claim 12 , wherein said calcium salt comprises at least one of calcium phosphate and calcium sulfate.
14. The implant of claim 13 , wherein said calcium phosphate comprises hydroxyapatite.
15. The implant of claim 1 , wherein said depot of material comprises at least one ceramic.
16. The implant of claim 15 , wherein said ceramic comprises at least one of calcium phosphate, calcium sulfate, and hydroxyapatite.
17. The implant of claim 1 , wherein said matrix further comprises reconstituted collagen.
18. The implant of claim 1 wherein said matrix and said material are resorbable, with said matrix resorbing at a different rate than said material.
19. The implant of claim 1 , wherein said depot of material acts as a carrier for at least one other constituent selected from the group consisting of a biologically active agent, a cellular material, a filler material, a polymer plasticizer, nanoparticles, and a coating material.
20. The implant of claim 1 , said implant further being in a bio-matched condition.
21. An implant for the repair or regeneration of tissue within the body of a living being, said implant comprising a matrix and a depot, said implant further being in a bio-matched condition, and further wherein at least a portion of said matrix further comprising soluble collagen and native insoluble collagen, wherein said native insoluble collagen comprises native collagen fibers, and wherein said at least a portion of said matrix defines pores of a diameter of greater than about 100 microns, and still further wherein said implant is arranged to be delivered to a site of a bone defect in a body of a living being.
22. The implant of claim 21 , wherein said bio-matched condition comprises integrity matched, porosity matched, compliance matched or weight matched.
23. The implant of claim 22 , wherein said integrity matched condition comprises a cross-linked condition.
24. The implant of claim 21 , wherein said depot comprises at least one ceramic.
25. The implant of claim 24 , wherein said ceramic comprises at least one of calcium phosphate, calcium sulfate, and hydroxyapatite.
26. The implant of claim 21 , wherein said bio-matched condition comprises a plurality of integrity matched, porosity matched, compliance matched, or weight matched conditions.
27. The implant of claim 21 , wherein said depot is in the form of a drug or biologic that acts as a depot for nutrients for proliferating and growing cells.
28. An implant for the repair or regeneration of bone tissue of a living being, said implant comprising a porous osteoconductive matrix and a depot of material, at least a portion of said matrix comprising soluble collagen and native insoluble collagen, wherein said native insoluble collagen comprises native collagen fibers, and wherein said at least a portion of said matrix defines pores of a diameter of greater than about 100 microns, wherein said implant comprises a form selected from the group consisting of loose fibrous material, a sponge, a paste/flowable material, a folded membrane, a woven or non-woven sheet, and pellets, and still further wherein said implant is arranged to be implanted within a body of a living being.