Systems and methods for controlling and forming polymer gels
View Patent ↗The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.
1. A method of controlling properties and forming a physically crosslinked, biocompatible hydrogel for a medical implant, wherein the method comprises the steps of:
(a) dissolving vinyl polymer molecules in a first solution to form a vinyl polymer solution, wherein the first solution has a Flory interaction parameter (chi value) that is not sufficient for gelation;
(b) contacting the vinyl polymer solution with a second solution in a controlled manner, wherein after the contacting the combination of both solutions has a Flory interaction parameter (chi value) that is sufficient for gelation in order to form a physically crosslinked, biocompatible hydrogel without chemical crosslinkers, irradiation or thermal cycling; and
(c) providing the physically crosslinked, biocompatible hydrogel formed in step (b) for the medical implant, wherein the medical implant is a load bearing or non-load bearing material for replacement, repair or enhancement of tissue.
2. The method according to claim 1 , wherein the first solution comprises one or more selected from the group consisting of deionized water and dimethylsulfoxide.
3. The method according to claim 1 , wherein the biocompatible polymer hydrogel is anisotropic in one or more properties.
4. The method of claim 1 , wherein the vinyl polymer solution comprises about 1.0 to about 50.0 weight percent polyvinyl alcohol.
5. The method of claim 1 , wherein after the contacting the Flory interaction parameter is 0.25 to 1.0.
6. The method of claim 1 , wherein the vinyl polymer solution contains one or more non-gelling components.
7. The method of claim 1 , wherein the vinyl polymer solution includes hyaluronic acid.
8. The method of claim 1 , wherein the vinyl polymer solution includes polyacrylic acid.
9. The method of claim 1 , wherein the vinyl polymer solution includes a therapeutic agent.
10. The method of claim 1 , wherein the vinyl polymer solution is placed in a dialysis chamber having at least two sides to permit introduction of a solution having a higher Flory interaction parameter than the vinyl polymer solution, wherein each side is a dialysis membrane that controls the rate of introduction of the solution having a higher Flory interaction parameter.
11. The method of claim 10 , wherein the vinyl polymer solution is separated by the membranes from at least two different solvents.
12. The method of claim 10 , wherein the vinyl polymer solution is separated by the membranes from a second solvent and a third solvent.
13. The method according to claim 1 , wherein the implant is selected from the group consisting of a hip implant, spine implant, knee implant, elbow implant, shoulder implant, wrist implant, hand implant, ankle implant, foot implant, jaw implant, breast implant and artificial cartilage.
14. A method of controlling properties and forming a physically crosslinked, biocompatible hydrogel for a medical device, wherein the method comprises the steps of:
(a) dissolving vinyl polymer molecules in a first solution to form a vinyl polymer solution, wherein the first solution has a Flory interaction parameter (chi value) that is not sufficient for gelation;
(b) contacting the vinyl polymer solution with a second solution in a controlled manner, wherein after the contacting the combination of both solutions has a Flory interaction parameter (chi value) that is sufficient for gelation in order to form a physically crosslinked, biocompatible hydrogel without chemical crosslinkers, irradiation or thermal cycling; and
(c) providing the physically crosslinked, biocompatible hydrogel formed in step (b) for the medical device, wherein the medical device is for humans or animals.
15. The method according to claim 14 , wherein the first solution comprises one or more selected from the group consisting of deionized water and dimethylsulfoxide.
16. The method according to claim 14 , wherein the biocompatible polymer hydrogel is anisotropic in one or more properties.
17. The method of claim 14 , wherein the vinyl polymer solution comprises about 1.0 to about 50.0 weight percent polyvinyl alcohol.
18. The method of claim 14 , wherein after the contacting the Flory interaction parameter is 0.25 to 1.0.
19. The method of claim 14 , wherein the vinyl polymer solution contains one or more non-gelling components.
20. The method of claim 14 , wherein the vinyl polymer solution includes hyaluronic acid.
21. The method of claim 14 , wherein the vinyl polymer solution includes polyacrylic acid.
22. The method of claim 14 , wherein the vinyl polymer solution includes a therapeutic agent.
23. The method of claim 14 , wherein the vinyl polymer solution is placed in a dialysis chamber having at least two sides to permit introduction of a solution having a higher Flory interaction parameter than the vinyl polymer solution, wherein each side is a dialysis membrane that controls the rate of introduction of the solution having a higher Flory interaction parameter.
24. The method of claim 23 , wherein the vinyl polymer solution is separated by the membranes from at least two different solvents.
25. The method of claim 23 , wherein the vinyl polymer solution is separated by the membranes from a second solvent and a third solvent.
26. The method according to claim 14 , wherein the medical device is selected from the group consisting of active bandages, trans-epithelial drug delivery devices, drug release structure, filters, microfluidic devices, sponges, anti-adhesion materials, artificial vitreous humor, contact lens, and stents.
27. The method according to claim 1 , wherein the implant is selected from the group consisting of a drug delivery device, drug release structure, filter, microfluidic device, sponge, anti-adhesion material, artificial vitreous humor, contact lens, breast implant, stent and artificial cartilage.