Use of alkylphosphocholines in combination with antitumor medications for the treatment of benign and malignant oncoses in humans and mammals
View Patent ↗The invention relates to the use of alkylphosphocholines in combination with antitumor medicaments for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or a combination of various approved cytostatics. Preferred alkylphosphocholines are described by the Formula II.
1. A method of treating mammary carcinoma, wherein said method comprises administering a therapeutically effective amount of octadecyl 1,1-dimethylpiperidinium-4-yl phosphate (perifosine) before and/or during treatment with an antimetabolite antitumor substance selected from the group consisting of 5-fluorouracil, fludarabine, cytarabine, and methotrexate.
2. The method of claim 1 wherein said antimetabolite antitumor substance is 5-fluorouracil.
3. The method of claim 1 wherein said antimetabolite antitumor substance is fludarabine.
4. The method of claim 1 wherein said antimetabolite antitumor substance is cytarabine.
5. The method of claim 1 wherein said antimetabolite antitumor substance is methotrexate.