Expandable processing and expression chamber
View Patent ↗A flexible processing and/or expressor chamber for a biological cell processing apparatus is provided which may include a first side and a second side and having a expandable wall, wherein a first end of the expandable wall is attached to a circumference of the first side of the flexible chamber and a second end of the expandable wall is attached to a circumference of the second side of the flexible chamber. Either or both sides of the chamber may include an axial opening.
1. A flexible centrifugal chamber comprising:
a first circular side wall with a first axial opening;
a second, opposing circular side wall with a second axial opening; and
an expandable wall extending between an outer circumference of each of the first and second opposing circular side walls, the expandable wall with a third axial opening larger than the first and second axial openings,
wherein the expandable wall is attached to the outer circumference of the first circular side wall of the flexible chamber and a second end of the expandable wall is attached to the outer circumference of the second, opposing circular side wall of the flexible chamber,
wherein the expandable wall includes at least one pair of corresponding connected partitions, a first partition of one of the at least one pair of partitions including a first circumferential end attached to the outer circumference of the first circular side wall, a second partition of one of the at least one pair of partitions including a second circumferential end attached to the outer circumference of the second circular side wall,
wherein the chamber is sterilized, having a variable volume capacity and adaptable to a continuous flow centrifuge.
2. The flexible chamber according to claim 1 , wherein the flexible centrifugal chamber comprises a processing chamber.
3. The flexible chamber according to claim 1 , wherein the flexible centrifugal chamber comprises an expressor chamber.
4. The flexible centrifugal chamber according to claim 1 , wherein the expandable wall comprises an accordion wall.
5. The flexible centrifugal chamber according to claim 1 , wherein the expandable wall includes a plurality of pairs of partitions.
6. The flexible chamber according to claim 1 , wherein the first axial opening is adaptable to connect to a hub and wherein the second axial opening is adaptable to connect to the hub.
7. A centrifuge processing apparatus, comprising a flexible centrifugal chamber comprising:
a first circular side wall with a first axial opening;
a second, opposing circular side wall with a second axial opening; and
a circumferential expandable wall extending between an outer circumference of each of the first and second opposing circular side walls, the expandable wall with a third axial opening larger than the first and second axial openings,
wherein a first end of the expandable wall is attached to the outer circumference of the first circular side wall of the flexible chamber and a second end of the expandable wall is attached to the outer circumference of the second, opposing circular side wall of the flexible chamber,
wherein the expandable wall includes at least one pair of corresponding connected partitions, a first partition of one of the at least one pair of partitions including a first circumferential end attached to the outer circumference of the first circular side wall, a second partition of one of the at least one pair of partitions including a second circumferential end attached to the outer circumference of the second circular side wall,
wherein the chamber is sterilized, having a variable volume capacity and adaptable to a continuous flow centrifuge.
8. The centrifuge processing apparatus according to claim 7 , wherein the axial openings of each of the first and second circular side walls are centered about a rotational axis of the flexible centrifugal chamber.
9. The centrifuge processing apparatus according to claim 7 , wherein the expandable wall comprises an accordion wall.
10. The centrifuge processing apparatus according to claim 7 , wherein the expandable wall includes a plurality of pairs of partitions.
11. The centrifuge processing apparatus according to claim 7 , wherein the flexible centrifugal chamber comprises a processing chamber for containing a material to be centrifuged.
12. The centrifuge processing apparatus according to claim 7 , wherein the flexible centrifugal chamber comprises an expressor chamber for containing an expressor material.
13. The centrifuge processing apparatus according to claim 7 , further comprising a plurality of flexible centrifugal chambers.
14. The centrifuge processing apparatus according to claim 13 , wherein one or more of the plurality of flexible centrifugal chambers comprise processing chambers for containing material to centrifuge and one or more of the plurality of flexible centrifugal chambers comprise expressor chambers for containing expressor material.
15. The centrifuge processing apparatus according to claim 7 , wherein the first axial opening is adaptable to connect to a hub and wherein the second axial opening is adaptable to connect to the hub.
16. A continuous flow centrifuge including a plurality of flexible centrifugal chambers, each centrifugal chamber of the plurality of centrifugal chambers respectively comprising:
a first circular side wall with a first axial opening; and
a second, opposing circular side wall with a second axial opening,
wherein each flexible centrifugal chamber further comprising a circumferential expandable wall extending between an outer circumference of each of the first and second opposing circular side walls, the expandable wall with a third axial opening larger than the first and second axial openings,
wherein a first end of the expandable wall is attached to an outer circumference of the first circular side wall of the respective flexible centrifugal chamber and a second end of the expandable wall is attached to an outer circumference of the second, opposing circular side wall of the respective flexible centrifugal chamber,
wherein the expandable wall includes at least one pair of corresponding connected partitions, a first partition of one of the at least one pair of partitions including a first circumferential end attached to the outer circumference of the first circular side wall, a second partition of one of the at least one pair of partitions including a second circumferential end attached to the outer circumference of the second circular side wall, at least one of the plurality of flexible centrifugal chambers being sterilized and having a variable volume capacity.
17. A biological cell processing apparatus comprising:
a continuous flow centrifuge; and
a sterilized flexible centrifugal chamber comprising:
a first circular side wall with a first axial opening;
a second, opposing circular side wall with a second axial opening; and
a circumferential expandable wall extending between an outer circumference of each of the first and second opposing circular side walls, the expandable wall with a third axial opening larger than the first and second axial openings,
wherein a first end of the expandable wall is attached to the outer circumference of the first circular side wall of the flexible chamber and a second end of the expandable wall is attached to the outer circumference of the second, opposing circular side wall of the flexible centrifugal chamber,
wherein the expandable wall includes at least one pair of corresponding connected partitions, a first partition of one of the at least one pair of partitions including a first circumferential end attached to the outer circumference of the first circular side wall a second partition of one of the at least one pair of partitions including a second circumferential end attached to the outer circumference of the second circular side wall.