G-protein coupled receptors
View Patent ↗The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of G-protein coupled receptors.
1. A preparation comprising a monoclonal antibody that specifically binds to the polypeptide of SEQ ID NO:6.
2. The preparation of claim 1 , wherein the antibody is a single chain Fv.
3. The preparation of claim 1 , wherein the antibody is humanized.
4. The preparation of claim 1 , wherein the antibody is an F(ab)′ 2 fragment.
5. The preparation of claim 1 , wherein the antibody is an Fab′ fragment.
6. The preparation of claim 1 , wherein the antibody is an Fab fragment.
7. The preparation of claim 6 , wherein the Fab fragment is a heteromeric Fab fragment.
8. The preparation of claim 1 , wherein the antibody is a chimeric antibody.