Radioactive magnetic fluids for treatment or diagnosis of cancer, process for preparing them and use thereof
The present invention relates to radioactive magnetic fluids, process for preparing them and use thereof. Particularly, the present invention relates to the radioactive magnetic fluids for treatment or diagnosis of cancer, process for preparing them and use thereof. The radioactive magnetic fluids of the present invention include the component of Cu 2+ which radiates a β-ray and γ-ray. The β radiation can effectively kill the tumor cells. Since the γ radiation are easily imaged with γ-camera, the magnetic fluids can be gathered to the treatment site with the radiograph under external magnetic field. Therefore, the radioactive magnetic fluids of the present invention can be used for treatment of cancer with minimal side effects. Also, the tightly bonded decanoic acid and nonanoic acid layer of the present invention not only increase particle-particle repulsion but also take hydrophilicity, to disperse homogeneously and stably the magnetic nanoparticles in water. Also, carboxylic acid of the surfactant is exposed to outside, to prevent the magnetic nanoparticles from being oxidized by air. Therefore, the radioactive magnetic fluids can be used as therapeutic drug or diagnostic reagent for cancer.
1. A radioactive magnetic fluid comprising: magnetic nanoparticles of Cu x Fe 1-x O·Fe 2 O 3 ; and surfactants coated onto the surface of the magnetic nanoparticles, wherein x value is between 0.1 and 0.4 and a component of copper in the magnetic nanoparticles of Cu x Fe 1-x O·Fe 2 O 3 is a radioactive copper.
2. The radioactive magnetic fluids according to claim 1 , wherein the magnetic nanoparticles of Cu x Fe 1-x O·Fe 2 O 3 are obtained by coprecipitating components of Fe 2+ and Fe 3+ with a component of radioactive Cu 2+ under presence of a precipitator.
3. The radioactive magnetic fluids according to claim 1 , wherein the surfactants comprise a first surfactant coated onto the surface of the magnetic nanoparticles, the first surfactant being decanoic acid, and a second surfactant coated onto the first-coated magnetic nanoparticles, the second surfactant being nonanoic acid.
4. A process for preparing the radioactive magnetic fluids of claim 1 , which comprises:
1) preparing the magnetic nanoparticles of Cu x Fe 1-x O·Fe 2 O 3 by coprecipitating the components of Fe 2+ and Fe 3+ with the component of radioactive Cu 2+ under presence of a precipitator;
2) first coating the magnetic nanoparticles with decanoic acid; and
3) second coating the first-coated magnetic nanoparticles with nonanoic acid.
5. The process according to claim 4 , wherein the precipitator is sodium hydroxide.
6. The process according to claim 4 , wherein the mole ratio of (Cu 2+ +Fe 2+ ) to Fe 3+ is within range of (1.1˜1.4):2.
7. A therapeutic drug for cancer containing the radioactive magnetic fluid according to claim 1 .
8. A diagnostic reagent for cancer containing the radioactive magnetic fluid according to claim 1 .