Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
View Patent ↗Embolic particles, as well as their methods of use and manufacture, are described.
1. A polymeric particle comprising a polyvinyl alcohol and having a diameter of about 500 microns or less, wherein the particle has a first density of pores in an interior region and a second density of pores at a surface region, the first density being different from the second density, and wherein the particle has a first average pore size in the interior region and a second average pore size at the surface region, the first average pore size being greater than the second average pore size.
2. The polymeric particle of claim 1 , wherein the second density is greater than the first density.
3. The polymeric particle of claim 1 , wherein the particle has a diameter of about 10 microns or more.
4. The polymeric particle of claim 1 , wherein the particle has a diameter of about 100 microns or more.
5. The polymeric particle of claim 4 , wherein the particle has a diameter of about 300 microns or less.
6. The polymeric particle of claim 1 , wherein the particle has a diameter of about 300 microns or more.
7. The polymeric particle of claim 1 , wherein the particle is at least partially coated with a substantially bioabsorbable material.
8. The polymeric particle of claim 1 , wherein the particle has a density of from about 1.1 grams per cubic centimeter to about 1.4 grams per cubic centimeter.
9. The polymeric particle of claim 1 , wherein the particle has a sphericity of about 0.9 or more.
10. The polymeric particle of claim 1 , wherein, after compression to about 50 percent, the particle has a sphericity of about 0.9 or more.
11. The polymeric particle of claim 1 , wherein the particle comprises about 2.5 weight percent or less polysaccharide.
12. The polymeric particle of claim 11 , wherein the polysaccharide comprises alginate.
13. The polymeric particle of claim 12 , wherein the alginate has a guluronic acid content of about 60 percent or greater.
14. The polymeric particle of claim 1 , wherein the particle is substantially insoluble in DMSO.
15. The polymeric particle of claim 1 , wherein the particle is substantially free of animal-derived compounds.
16. A polymeric particle comprising a polyvinyl alcohol and having a diameter of about 500 microns or less, wherein the particle has a first average pore size in an interior region and a second average pore size at a surface region, the first average pore size being greater than the second average pore size.
17. The polymeric particle of claim 16 , wherein the particle has a diameter of about 10 microns or more.
18. The polymeric particle of claim 16 , wherein the particle has a diameter of about 100 microns or more.
19. The polymeric particle of claim 18 , wherein the particle has a diameter of about 300 microns or less.
20. The polymeric particle of claim 16 , wherein the particle has a diameter of about 300 microns or more.
21. The polymeric particle of claim 16 , wherein the particle comprises about 2.5 weight percent or less polysaccharide.
22. The polymeric particle of claim 21 , wherein the polysaccharide comprises alginate.
23. A composition, comprising:
a plurality of particles, at least some of the plurality of particles comprising a polyvinyl alcohol and having a diameter of about 500 microns or less, wherein at least some of the particles having a diameter of about 500 microns or less have a first density of pores and a first average pore size in an interior region and a second density of pores and a second average pore size at a surface region, the first density being different from the second density, and the first average pore size being greater than the second average pore size; and
a carrier fluid, the plurality of particles being in the carrier fluid.
24. The composition of claim 23 , wherein the carrier fluid comprises a saline solution.
25. The composition of claim 23 , wherein the carrier fluid comprises a contrast agent.
26. The composition of claim 23 , wherein the plurality of particles has a mean diameter of about 500 microns or less.
27. The composition of claim 23 , wherein the plurality of particles has a mean diameter of about 10 microns or more.
28. The composition of claim 23 , wherein the plurality of particles has a mean diameter of about 100 microns or more.
29. The composition of claim 28 , wherein the plurality of particles has a mean diameter of about 300 microns or less.
30. The composition of claim 23 , wherein the plurality of particle has a mean diameter of about 300 microns or more.
31. A composition, comprising:
a plurality of particles, at least some of the plurality of particles comprising a polyvinyl alcohol and having a diameter of about 500 microns or less, wherein at least some of the particles having a diameter of about 500 microns or less have a first average pore size in an interior region and a second average pore size at a surface region, the first average pore size being greater than the second average pore size; and
a carrier fluid, the plurality of particles being in the carrier fluid.
32. The composition of claim 31 , wherein the plurality of particles has a mean diameter of about 500 microns or less.
33. The composition of claim 31 , wherein the plurality of particles has a mean diameter of about 10 microns or more.
34. The composition of claim 31 , wherein the plurality of particles has a mean diameter of about 100 microns or more.
35. The composition of claim 34 , wherein the plurality of particles has a mean diameter of about 300 microns or less.
36. The composition of claim 31 , wherein the plurality of particle has a mean diameter of about 300 microns or more.
37. A polymeric particle comprising a polysaccharide and having a diameter of about 500 microns or less, wherein the particle has an interior region defining pores and a surface region defining pores, the particle has a first density of pores in the interior region and a second density of pores at the surface region, the first density being different from the second density, and the particle has a first average pore size in the interior region and a second average pore size at the surface region, the first average pore size being greater than the second average pore size.
38. The polymeric particle of claim 37 , wherein the particle has a diameter of about 10 microns or more.
39. The polymeric particle of claim 37 , wherein the particle has a diameter of about 100 microns or more.
40. The polymeric particle of claim 39 , wherein the particle has a diameter of about 300 microns or less.
41. The polymeric particle of claim 37 , wherein the particle has a diameter of about 300 microns or more.
42. The polymeric particle of claim 37 , wherein the particle comprises about 2.5 weight percent or less of the polysaccharide.
43. The polymeric particle of claim 42 , wherein the polysaccharide comprises alginate.