Treating of cardiovascular and related pathologies
View Patent ↗Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
1. A method of reducing blood clots in a mammal comprising: concurrently administering to the mammal a therapeutically effective amount for reducing blood clots of a combination of a compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, and a mixture thereof, and a cardiovascular compound selected from the group consisting of pyridoxal phophate-6-azophenyl-2′,4′-disulphonic acid (PPADS) and an anti-thrombotic agent, wherein the 3-acylated pyridoxal analogue is a compound of the formula
wherein
R 1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom; an alkoxy group; a dialkylamino group; or an unsubstituted or substituted aryl group; and
R 2 is a secondary amino group.
2. A method according to claim 1 , wherein the 3-acylated pyridoxal analogue is a compound of the formula
wherein
R 1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom; an alkoxy group; a dialkylamino group; or an unsubstituted or substituted aryl group.
3. A method according to claim 1 , wherein the 3-acylated pyridoxal analogue is a compound of the formula
wherein
R 1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom; an alkoxy group; a dialkylamino group; or an unsubstituted or substituted aryl group; and
R 2 is a secondary amino group.
4. A method according to claim 1 , wherein the anti-thrombotic agent is an antiplatelet agent, aspirin, or heparin.
5. A method according to claim 1 , wherein the compound is administered enterally or parenterally and the anti-thrombotic agent is administered enterally or parenterally.
6. A method according to claim 1 , wherein the compound and the anti-thrombotic agent are administered in a single dosage form.