Ointment wound spray
View Patent ↗A spray-on topical wound debrider spray is prepared forming a mist, spray or foam which will not drip significantly after application. The preferred wound debrider is papain. The spray contains a surfactant emulsifier admixture having a composition viscosity of from about 5000 cps to about 50,000 cps and is preferably a fatty alcohol phosphate ester emulsifier composition.
1. A spray-on topical wound debrider composition comprising:
(a) an effective amount of a proteolytic enzyme wound debrider; and
(b) a surfactant emulsifier admixture to provide an emulsion containing the wound debrider and having a composition viscosity of from about 5000 cps to about 50,000 cps, wherein the surfactant emulsifier is present in an amount of from 1% by weight to 20% by weight of the total composition and wherein the surfactant emulsifier is a cryptoanionic comprising an alkoxylated fatty alcohol and mono and diester phosphates; and
(c) at least one wound healing agent, emollient, humectant, preservative, or anti-microbial,
wherein the composition is capable of forming a mist, spray or foam which will not drip significantly after application.
2. The composition of claim 1 wherein the composition is contained in a non-aerosol pump container.
3. The composition of claim 1 wherein the composition is contained in a pressurized aerosol container.
4. The composition of claim 1 wherein the proteolytic enzyme is present at an amount of from 0.001% to 20% by weight of the composition.
5. The composition of claim 4 wherein the proteolytic enzyme is present at an amount of from 0.01% to 10% by weight of the composition.
6. The composition of claim 1 wherein the surfactant emulsifier admixture provides a composition viscosity of from about 15,000 cps to about 40,000 cps.
7. The composition of claim 1 which has a pH of from about 3 to about 8.
8. The composition of claim 7 which has a pH of from about 4 to about 7.
9. The composition of claim 1 wherein the proteolytic enzyme is selected from the group consisting of papain, trypsin, chymo-trypsin, streptokinaise, streptodormase, ficin, pepsin, bromelin, thermolysin, thermoase, and subtilisin.
10. The composition of claim 9 where in the proteolytic enzyme is selected from the group consisting of papain, trypsin, and thermolysin, and thermoase.
11. The composition of claim 1 , wherein the surfactant emulsifier is present in an amount from 2% by weight to 10% by weight of the total composition.
12. A spray-on topical wound debrider composition comprising:
(a) an effective amount of a proteolytic enzyme wound debrider; and
(b) a surfactant emulsifier admixture to provide an emulsion containing the wound debrider and having a composition viscosity of from about 5000 cps to about 50,000 cps; and
(c) at least one wound healing agent, emollient, humectant, preservative, or anti-microbial,
wherein the composition is contained in a pressurized aerosol container and is capable of forming a mist, spray or foam which will not drip significantly after application.
13. The composition of claim 12 wherein the proteolytic enzyme is present at an amount of from 0.001% to 20% by weight of the composition.
14. The composition of claim 13 wherein the proteolytic enzyme is present at an amount of from 0.01% to 10% by weight of the composition.
15. The composition of claim 12 wherein the surfactant emulsifier admixture provides a composition viscosity of from about 15,000 cps to about 40,000 cps.
16. The composition of claim 12 which has a pH of from about 3 to about 8.
17. The composition of claim 16 which has a pH of from about 4 to about 7.
18. The composition of claim 12 wherein the proteolytic enzyme is selected from the group consisting of papain, trypsin, chymo-trypsin, streptokinaise, streptodormase, ficin, pepsin, bromelin, thermolysin, thermoase, and subtilisin.
19. The composition of claim 18 where in the proteolytic enzyme is selected from the group consisting of papain, trypsin, and thermolysin, and thermoase.
20. The composition of claim 12 wherein the surfactant emulsifier is present in an amount of from 1% to 20% by weight of the total composition.
21. The composition of claim 12 wherein the surfactant emulsifier is present in an amount of from 2% by weight to 10% by weight of the total composition.
22. The composition of claim 12 wherein the surfactant emulsifier is selected from the group consisting of anionics, cationics, nonionics, and cryptoanionics.
23. The composition of claim 22 , wherein the surfactant emulsifier is a cryptoanionic.
24. The composition of claim 23 , wherein the cryptoanionic comprises an alkoxylated fatty alcohol and mono and diester phosphates.
25. A spray-on topical wound debrider composition comprising:
(a) an effective amount of a proteolytic enzyme wound debrider; and
(b) a surfactant emulsifier admixture to provide an emulsion containing the wound debrider and having a composition viscosity of from about 5000 cps to about 50,000 cps, wherein the surfactant emulsifier is present in an amount of from 1% by weight to 20% by weight of the total composition and wherein the surfactant emulsifier is a cryptoanionic comprising an alkoxylated fatty alcohol and mono and diester phosphates; and
wherein the compositions is contained in a pressurized aerosol container and is capable of forming a mist, spray or foam which will not drip significantly after application.
26. The composition of claim 25 wherein the proteolytic enzyme is present at an amount of from 0.001% to 20% by weight of the composition.
27. The composition of claim 26 wherein the proteolytic enzyme is present at an amount of from 0.01% to 10% by weight of the composition.
28. The composition of claim 25 wherein the surfactant emulsifier admixture provides a composition viscosity of from about 15,000 cps to about 40,000 cps.
29. The composition of claim 25 , further comprising at least one wound healing agent, emollient, humectant, preservative, or anti-microbial.
30. The composition of claim 25 which has a pH of from about 3 to about 8.
31. The composition of claim 30 which has a pH of from about 4 to about 7.
32. The composition of claim 25 wherein the proteolytic enzyme is selected from the group consisting of papain, trypsin, chymo-trypsin, streptokinaise, streptodormase, ficin, pepsin, bromelin, thermolysin, thermoase, and subtilisin.
33. The composition of claim 32 where in the proteolytic enzyme is selected from the group consisting of papain, trypsin, and thermolysin, and thermoase.
34. The composition of claim 25 wherein the surfactant emulsifier is present in an amount of from 2% by weight to 10% by weight of the total composition.