Devices and methods for treating defects in the tissue of a living being
View Patent ↗An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
1. An implant for the repair or regeneration of a defect in a bone of a living being, said implant comprising an osteoconductive matrix and at least one calcium salt blended into said matrix, wherein at least a portion of said matrix comprises a mixture of native insoluble collagen and soluble collagen, wherein said native insoluble collagen is in the form of native collagen fibers, wherein said implant is porous and is suitable for placement into a body of a living being during an implant procedure, and wherein said pores are at least about 100 microns in size.
2. The implant of claim 1 , wherein said calcium salt is at least one of a calcium phosphate and a calcium sulfate.
3. The implant of claim 2 , wherein said calcium phosphate is at least one of tricalcium phosphate and hydroxyapatite.
4. The implant of claim 2 , wherein said calcium phosphate comprises from about ten to about ninety percent of the weight of the implant.
5. The implant of claim 4 , wherein the ratio of said native insoluble collagen to soluble collagen is from about 10:1 to 1:20.
6. The implant of claim 1 , wherein said matrix additionally comprises at least one additive.
7. The implant of claim 6 , wherein said at least one additive comprises at least one of ceramics, biologically active agents, drugs, and therapies.
8. The implant of claim 7 , wherein said at least one additive is dispersed throughout the implant.
9. The implant of claim 7 , wherein said biologically active agent comprises at least one of bone marrow, autologous blood, and bone morphogenic protein.
10. The implant of claim 6 , wherein said additive is added to the implant at, or immediately prior to, placement of said implant into said tissue.
11. The implant of claim 10 , wherein said osteoconductive matrix is dry and said additive is liquid, such that said additive hydrates said matrix upon the addition thereof.
12. The implant of claim 2 , wherein said matrix is arranged to be compressed.
13. The implant of claim 12 , wherein said compression occurs during the implant procedure.
14. The implant of claim 13 , wherein said compression causes said implant to conform to the shape of the defect being treated.
15. The implant of claim 1 , wherein said soluble collagen is not cross-linked.