Treatment of obesity by sub-diaphragmatic nerve stimulation
View Patent ↗A method and apparatus for treating obese or other patients with compulsive overeating disorder includes unilaterally or bilaterally stimulating one or both of the left and right branches of a patient's vagus nerve directly or indirectly with an electrical pulse signal generated by an implantable neurostimulator with at least one operatively coupled nerve electrode to apply the pulse signal to the selected nerve branch at a location below the patient's diaphragm. The implantable neurostimulator is programmable to enable physician programming of electrical and timing parameters of the pulse signal, to induce weight loss of the patient.
1. A method of treating an obese patient, comprising:
surgically implanting in the abdomen of the patient an electrical signal generator and electrodes operatively coupled thereto for generating and applying said electrical signal internally at a location below the patient's diaphragm to indirectly stimulate a selected one of the left branch and the right branch of the vagus nerve;
applying said electrical signal indirectly and unilaterally to said selected one of the left branch and the right branch of the vagus nerve internally in the abdomen at said location below the patient's diaphragm; and
programming electrical and timing parameters of said electrical signal, to induce weight loss of the patient.
2. The method of claim 1 , wherein said electrical signal comprises a sequence of electrical pulses.
3. The method of claim 1 , wherein the step of applying comprises applying said electrical signal to the selected one of the left branch and the right branch of the vagus nerve at a location in a range of from about two to about three inches below the patient's diaphragm.
4. The method of claim 1 , wherein the step of applying comprises applying said electrical signal intermittently, in alternating on and off intervals according to a predetermined duty cycle.
5. The method of claim 1 , wherein the step of applying includes applying said electrical signal continuously.
6. A method of treating a patient with compulsive eating disorder, said method comprising:
applying an electrical signal to the vagus nerve of the patient at a sub-diaphragmatic location to induce a signal in the nerve toward the patient's brain, and
programming electrical and timing parameters of said electrical signal to control said eating disorder,
wherein said applying comprises indirectly and unilaterally stimulating a selected one of the left branch and the right branch of the vagus nerve in the vicinity of the sub-diaphragmatic location by applying said electrical signal internally at said sub-diaphragmatic location which is removed from said selected left or right branch of the vagus nerve, by way of at least one electrode surgically implanted in the abdomen of the patient at the sub-diaphragmatic location.
7. The method of claim 6 , wherein said electrical signal comprises a sequence of electrical pulses.
8. The method of claim 6 , wherein the step of applying comprises applying said electrical signal to the selected one of the right branch and the left branch of the vagus nerve at said location in a range of from about two to about three inches below the patient's diaphragm.
9. A method of treating a patient with compulsive eating disorder, said method comprising:
surgically implanting at least one pulse generator with surgically implanted nerve electrodes coupled thereto into the abdomen of the patient to generate and apply an electrical signal as a sequence of electrical impulses indirectly and unilaterally to a selected one of the left branch and the right branch of the vagus nerve;
programming electrical and timing parameters of said electrical signal to control said eating disorder, and
applying said electrical signal indirectly and unilaterally to said selected one of the left branch and the right branch of the vagus nerve of the patient at a sub-diapbragmatic location, to induce a signal in the nerve toward the patient's brain to control said eating disorder of the patient.