Fast dissolving tablet
View Patent ↗The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.
1. A tablet consisting of a fast dissolve granulation, an active ingredient, mannitol, sucralose, a flavor, a disintegrant, corn starch and silicon dioxide wherein the fast dissolve granulation consists essentially of a portion of the mannitol and a low melting point compound that melts or softens at or below 37° C. selected from the group consisting of hydrogenated vegetable oil, and partially hydrogenated vegetable oil and wherein the low melting point compound comprises less than about 20% (wt/wt) of the fast dissolve granulation and from about 0.01% to about 2.5% (wt/wt) of the tablet, and wherein the tablet has a hardness of less than 1.5 kP and is a fast dissolving tablet.
2. A tablet consisting of a fast dissolve granulation, an active ingredient, mannitol, sucralose, a flavor, a disintegrant, corn starch, silicon dioxide and a souring agent wherein the fast dissolve granulation consists essentially of a portion of the mannitol and a low melting point compound that melts or softens at or below 37° C. selected from the group consisting of hydrogenated vegetable oil, and partially hydrogenated vegetable oil and wherein the low melting point compound comprises less than about 20% (wt/wt) of the fast dissolve granulation and from about 0.01% to about 2.5% (wt/wt) of the tablet, and wherein the tablet has a hardness of less than 1.5 kP and is a fast dissolving tablet.