Materials and methods for the treatment of hypertension and angina
View Patent ↗The subject invention provides useful and novel calcium channel blockers based upon mibefradil. The subject invention also provides methods for synthesizing the compounds of the invention. The invention also provides methods for the control or prevention of hypertension, angina pectoris, ischemia, arrhythmias, and cardiac insufficiency in a patient by administering a compound, or composition, of the invention to an individual in need of such treatment.
1. A method for blocking a calcium channel in a patient in need of such blocking wherein said method comprises administering to said patient a calcium channel blocking compound wherein said compound has the following structure:
wherein:
X=a bond, (CH 2 ) n , O, or O(CH 2 ) n ,
wherein n=1-6;
R 1 =C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 2 =F or COOR 5 ,
wherein R 5 is C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 3 =CH 3 or (CH 2 ) n —COOR 6 ,
wherein n=1-6 and R 6 is C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 4 =
R 15 =(CH 2 ) n COOR 16 ,
R 16 =C 1-6 alkyl, optionally substituted with OH or NH 2 , and
R 17 =not present or COOR 18 wherein R 18 is C 1-6 alkyl, optionally substituted with OH or NH 2 , and
wherein n=1-6.
2. A method for blocking a calcium channel in a patient in need of such blocking wherein said method comprises administering to said patient a calcium channel blocking compound wherein said compound has a formula selected from the group consisting of:
X=bond, OH 2 , or OCH 2
R=lower alkyl optionally substituted OH or NH 2 ;
R=lower alkyl optionally substituted by OH or NH 2 ;
n=1 to 3
R=lower alkyl optionally substituted by OH or NH 2 ;
n=1 to 3
R=lower alkyl optionally substituted by OH or NH 2 ; and
R=lower alkyl optionally substituted by OH or NH 2 .
3. The compound, according to claim 2 , wherein said compound has the following structure:
X=bond, CH 2 , or OCH 2
R=lower alkyl optionally substituted OH or NH 2 .
4. The compound, according to claim 2 , wherein said compound has the following structure:
R=lower alkyl optionally substituted by OH or NH 2 .
5. The compound, according to claim 2 , wherein said compound has the following structure:
n=1 to 3
R=lower alkyl optionally substituted by OH or NH 2 .
6. The compound, according to claim 2 , wherein said compound has the following structure:
n=1 to 3
R=lower alkyl optionally substituted by OH or NH 2 .
7. The compound, according to claim 2 , wherein said compound has the following structure:
R=lower alkyl optionally substituted by OH or NH 2 .
8. The method, according to claim 1 , wherein the patient is a human.
9. The method, according to claim 1 , wherein said method is used to treat a condition selected from the group consisting of hypertension, angina, ischemia, arrhythmia, congestive heart failure, and cardiac insufficiency.
10. A method for blocking a calcium channel in a patient in need of such blocking wherein said method comprises administering to said patient a calcium channel blocking compound wherein said compound has the following structure:
wherein:
X=a bond, (CH 2 ) n , O, or O(CH 2 ) n ,
wherein n=1-6;
R 1 =C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 2 =F or COOR 5 ,
wherein R 5 is C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 3 =(CH 2 ) n —COOR 6 ,
wherein n=1-6 and R 6 is C 1-6 alkyl, optionally substituted with OH or NH 2 ;
R 4 =
R 15 =is H,
R 17 =not present or COOR 18 wherein R 18 is C 1-6 alkyl, optionally substituted with OH or NH 2 , and
wherein n=1-6.