Delivery of a therapeutic agent in a formulation for reduced toxicity
View Patent ↗Methods and compositions for reducing toxicity of a toxic agent are provided in which a polysaccharide, galactomannan is coadministered with a therapeutic agent in a liquid formulation to a subject to reduce toxicity of the agent for the subject.
1. A cancer therapeutic formulation having reduced toxicity, comprising, an effective dose of a galactomannan, and an effective dose of a chemotherapeutic agent in a mixture.
2. A cancer therapeutic formulation according to claim 1 wherein the formulation is in a powder form.
3. A cancer therapeutic formulation according to claim 1 wherein the formulation is in a liquid form.
4. A pharmaceutical formulation, comprising: a mixture of galactomannan polysaccharide and an effective dose for treating cancer of a chemotherapeutic agent in a pharmaceutically acceptable formulation.
5. The pharmaceutical formulation of claim 4 , wherein the mixture comprises an amount of galactomannan and the chemotherapeutic agent in the ratio suitable for reducing a toxic effect in the subject, the toxic effect resulting from administration of a cancer treating amount of chemotherapeutic agent absent galactomannan.
6. The pharmaceutical formulation of claim 4 , wherein the mixture comprises an amount of galactomannan and the chemotherapeutic agent in a ratio suitable for enhancing efficacy of chemotherapeutic effect for treating the cancer.
7. The pharmaceutical formulation of claim 4 , wherein the chemotherapeutic agent is 5-FU.
8. The pharmaceutical formulation of claim 4 , wherein the chemotherapeutic agent is adriamycin.
9. The formulation of claim 5 or 6 , wherein the formulation is in a powder form.
10. The formulation of claim 5 or 6 , wherein the formulation is in a liquid form.