Delivery of a therapeutic agent in a formulation for reduced toxicity

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Quick Facts

Patent No.: US 6,982,255
App. No.: 10/649,131
Granted: Jan 3, 2006
Kind: B2

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Abstract

Methods and compositions for reducing toxicity of a toxic agent are provided in which a polysaccharide, galactomannan is coadministered with a therapeutic agent in a liquid formulation to a subject to reduce toxicity of the agent for the subject.

Claims (7)

1. A method for treating a cancer in a subject, comprising administering parenterally an effective dose of a chemotherapeutic agent in a mixture with an effective dose of a galactomannan to said subject in need thereof.

2. A method according to claim 1 , wherein the cancer is a tumor and the chemotherapeutic agent is adriamycin.

3. A method according to claim 1 , wherein the cancer is a tumor and the chemotherapeutic agent is 5-FU.

4. A method according to claim 1 , wherein the galactomannan has a molecular weight of 83,000 D.

5. A method according to claim 1 , wherein the galactomannan has a molecular weight of 215,000 D.

6. A method according to claim 2 , wherein the ratio of mannose to galactose is 1.13:1.

7. A method according to claim 3 , wherein the ratio of mannose to galactose is 2.2:1.

Assignments (9)

RELEASE OF SECURITY INTEREST Recorded Sep 17, 2019

From: 10X FUND L.P.

To: GALECTIN THERAPEUTICS, INC.

Reel/Frame 050399/0679 →

CHANGE OF NAME Recorded Oct 18, 2012