Process for the modification of elastomers with surface interpenetrating polymer networks and elastomers formed therefrom
View Patent ↗A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of absorbing a swelling monomer into the polymer substrate for a period of time in order to swell the polymer substrate; removing the swollen polymer from the swelling monomer; transferring the swollen polymer to a reaction mixture containing at least one functional monomer; polymerizing the functional monomer in the reaction mixture containing the swollen polymer substrate for a period of time; and removing the polymer from the reaction mixture. Because the surface modification produced by the process is a surface interpenetrating polymer network, the process is not sensitive to the reactive groups located on the surface of the polymer substrate. Further, the surface interpenetrating network bonds to the polymer substrate through caternary connections or other forms of chain entanglement and this is quite stable. Polymer substrates having the surface modification of the present invention are capable of having a surface modification agent, such as heparin, adhere to the surface of the polymer substrate.
1. A process for the surface modification of a silicone substrate, the process comprising the steps of:
a. absorbing ethylene glycol dimethacrylate into silicone for between approximately 0.1 hours to 72 hours at a temperature of between approximately 0° C. and 100° C. in order to swell the silicone;
b. removing the swollen silicone from the ethylene glycol dimethacryate;
c. transferring the swollen silicone into an aqueous solution containing 2-aminoethyl methacrylate hydrochloride in a concentration of between approximately 0.1% and 50% and 2,2′-azobis(2-methylpropionamidine) dihydrochloride in a concentration of between approximately 0.1% and 10%;
d. contacting the swollen silicone with the 2-aminoethyl methacrylate hydrochloride and the 2,2′-azobis(2-methylpropionamidine) dihydrochloride at a temperature of between approximately 30° C. and 80° C. for between approximately 0.1 hours and 24 hours; and
e. removing the silicone from the aqueous solution.
2. A process for forming a surface interpenetrating polymer network on a silicone substrate, the process comprising the steps of:
a. absorbing bis(2-methacryloxyethyl) phosphate into silicone for between approximately 0.1 hours and 72 hours at room temperature in order to swell the silicone;
b. removing the swollen silicone from the bis(2-methacryloxyethyl) phosphate;
c. transferring the swollen silicone into an aqueous solution containing 2-aminoethyl methacrylate hydrochloride in a concentration of between approximately 0.1% to 50% and 2-hydroxy-2-methyl-1-phenylpropanone in a concentration of between approximately 0.1% and 10%.
d. contracting the swollen silicone with the 2-aminoethyl methacrylate hydrochloride and the 2-hydroxy-2-methyl-1-phenylpropanone at a temperature of between approximately 30° C. and 80° C. for between approximately 1 minute to 10 hours with UV radiation; and
e. removing the silicone from the aqueous solution.
3. A silicone contact lens having the surface modification formed by the process of claim 1 .
4. A silicone contact lens having the surface modification formed by the process of claim 2 .