LbL-coated medical device and method for making the same
View Patent ↗The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
1. A medical device, comprising a core material and a biocompatible LbL coating non-covalently attached to said core material, wherein said biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material, wherein said charged polymeric material is a first polyanionic polymer or a mixture of two or more polyanionic polymers, and wherein said non-charged material is a homopolymer of a vinyl lactam of formula (I), a coplymer of at least one vinyl lactam of formula (I) in the presence or in the absence of one or more hydrophilic vinylic comonomers, or mixture thereof
wherein
R is an alkylene di-radical having from 2 to 8 carbon atoms,
R 1 is hydrogen, C 1 -C 10 alkyl, aryl having up to 10 carbon atoms, aralkyl or alkaryl having up to 14 carbon atoms, and
R 2 is hydrogen or C 1 -C 10 alkyl.
2. A medical device of claim 1 , wherein said medical device is an ophthalmic device.
3. A medical device of claim 2 , wherein said ophthalmic device is a contact lens.
4. A contact lens of claim 3 , wherein said core material is a hydrogel.
5. A contact lens of claim 4 , wherein said hydrogel is a siloxane-containing polymer.
6. A medical device of claim 2 , wherein R is a C 2 -C 4 alkylene di-radical, and wherein R 1 and R 2 are each independently of the other hydrogen or C 1 -C 7 alkyl.
7. A medical device of claim 2 , wherein said non-charged material is a homopolymer of N-vinyl-2-pyrrolidone, N-vinyl-2-piperidone, N-vinyl-2-caprolactam, N-vinyl-3-methyl-2-pyrrolidone, N-vinyl-3-methyl-2-piperidone, N-vinyl-3-methyl-2-caprolactam, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl4-methyl-2-caprolactam, N-vinyl-5-methyl-2-pyrrolidone, N-vinyl-5-methyl-2-piperidone, N-vinyl-5,5-dimethyl-2-pyrrolidone, N-vinyl-3,3,5-trimethyl-2-pyrrolidone, N-vinyl-5-methyl-5-ethyl-2-pyrrolidone, N-vinyl-3,4,5-trimethyl-3-ethyl-2-pyrrolidone, N-vinyl-6-methyl-2-piperidone, N-vinyl-6-ethyl-2-piperidone, N-vinyl-3,5-dimethyl-2-piperidone, N-vinyl-4,4-dimethyl-2-piperidone, N-vinyl-7-methyl-2-caprolactam, N-vinyl-7-ethyl-2-caprolactam, N-vinyl-3,5-dimethyl-2-caprolactam, N-vinyl-4,6-dimethyl-2-caprolactam or N-vinyl-3,5,7-trimethyl-2-caprolactam.
8. A medical device of claim 7 , wherein said non-charged material is a copolymer of two or more of N-vinyl-2-pyrrolidone, N-vinyl-2-piperidone, N-vinyl-2-caprolactam, N-vinyl-3-methyl-2-pyrrolidone, N-vinyl-3-methyl-2-piperidone, N-vinyl-3-methyl-2-caprolactam, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl-4-methyl-2-caprolactam, N-vinyl-5-methyl-2-pyrrolidone, N-vinyl-5-methyl-2-piperidone, N-vinyl-5,5-dimethyl-2-pyrrolidone, N-vinyl-3,3,5-trimethyl-2-N-vinyl-5-methyl-5-ethyl-2-pyrrolidone, N-vinyl-3,4,5-trimethyl-3-ethyl-2-pyrrolidone, N-vinyl-6-methyl-2-piperidone, N-vinyl-6-ethyl-2-piperidone, N-vinyl-3,5-dimethyl-2-piperidone, N-vinyl-4,4-dimethyl-2-piperidone, N-vinyl-7-methyl-2-caprolactam, N-vinyl-7-ethyl-2-caprolactam, N-vinyl-3,5-dimethyl-2-caprolactam, N-vinyl-4,6-dimethyl-2-caprolactam and N-vinyl-3,5,7-trimethyl-2-caprolactam.
9. A medical device of claim 2 , wherein said first polyanionic polymer is a copolymerization product of acrylic acid, methacrylic acid, or mixture thereof with acrylamide, N,N-dimethyl acrylamide, N-vinyl-2-pyrrolidone, N-vinyl-2-piperidone, N-vinyl-2-caprolactam, N-vinyl-3-methyl-2-pyrrolidone, N-vinyl-3-methyl-2-piperidone, N-vinyl-3-methyl-2-caprolactam, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl-4-methyl-2-caprolactam, N-vinyl-5-methyl-2-pyrrolidone, N-vinyl-5-methyl-2-piperidone, N-vinyl-5,5-dimethyl-2-pyrrolidone, N-vinyl-3,3,5-trimethyl-2-pyrrolidone, N-vinyl-5-methyl-5-ethyl-2-pyrrolidone, N-vinyl-3,4,5-trimethyl-3-ethyl-2-pyrrolidone, N-vinyl-6-methyl-2-piperidone, N-vinyl-6-ethyl-2-piperidone, N-vinyl-3,5-dimethyl-2-piperidone, N-vinyl-4,4-dimethyl-2-piperidone, N-vinyl-7-methyl-2-caprolactam, N-vinyl-7-ethyl-2-caprolactam, N-vinyl-3,5-dimethyl-2-caprolactam, N-vinyl-4,6-dimethyl-2-caprolactam, N-vinyl-3,5,7-trimethyl-2-caprolactam, or mixtures thereof.
10. A medical device of claim 2 , wherein said biocompatible LbL coating further comprises at least one layer of a polycationic polymer or of a mixtures of polycationic polymers.
11. A medical device of claim 2 , wherein said biocompatible LbL coating comprises 2 to 20 charge/non-charge bilayers.
12. A medical device of claim 11 , wherein said biocompatible LbL coating comprises 4 to 10 charge/non-charge bilayers.
13. A medical device of claim 2 , wherein said biocompatible LbL coating further comprises at least one layer of second polyanionic polymer.