IP Library › Granted Patent US 7,091,245

Granted Patent B2

US 7,091,245 · App. 10/654,699 · Granted Aug 15, 2006

Compounds, their preparation and use

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Quick Facts

Patent No.: US 7,091,245
App. No.: 10/654,699
Granted: Aug 15, 2006
Kind: B2

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Abstract

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.

Claims (508)

1. A compound of formula (I):

wherein X 1 is aryl or heteroaryl each of which is optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylcarbonyl, arylcarbonyl, C 1-6 -alkylsulfonyl, arylsulfonyl, C 1-6 -alkylamido, arylamido, C 1-6 -alkylaminocarbonyl, C 1-6 -dialkylaminocarbonyl, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted with one or more halogens; and

X 2 is arylene or heteroarylene each of which is optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, C 1-6 -alkylthio, C 3-6 -cycloalkylthio, C 1-6 -alkylamino, C 1-6 -dialkylamino or C 3-6 -cycloalkylamino each of which is optionally substituted with one or more halogens; and

X 3 is aryl or heteroaryl each of which is optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

X 4 is arylene or heteroarylene each of which is optionally substituted with one or more substituents selected from

halogen, hydroxy, cyano, amino or carboxy; or

Ar is arylene which is optionally substituted with one or more substituents selected from

halogen, hydroxy or cyano; or

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heteroaryl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted with one or more halogens; and

Y 1 is O or S; and

Y 2 is O or S; and

Z is —(CH 2 ) n — wherein n is 1, 2 or 3; and

R 1 is hydrogen, halogen or a substituent selected from

C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aralkyl, heteroaralkyl, C 1-6 -alkoxy, C 3-6 -cycloalkoxy, aryloxy, aralkoxy, heteroaralkoxy, C 1-6 -alkylthio, arylthio or C 3-6 -cycloalkylthio each of which is optionally substituted with one or more halogens; and

R 2 is hydrogen, C 1-6 -alkyl, C 3-6 -cycloalkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 4-6 -alkenynyl or aryl; or

a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or any tautomeric forms, stereoisomers, mixture of stereoisomers, racemic mixture, or polymorphs thereof.

2. A compound according to claim 1 , wherein X 1 is aryl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

C 1-6 -alkyl, aryl, heteroaryl, C 1-6 -alkoxy, C 1-6 -alkylthio, C 1-6 -alkylcarbonyl, C 1-6 -alkylsulfonyl, arylamido, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

3. A compound according to claim 2 , wherein X 1 is aryl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

4. A compound according to claim 2 , wherein X 1 is phenyl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

5. A compound according to claim 4 , wherein X 1 is phenyl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

6. A compound according to claim 1 , wherein X 1 is heteroaryl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

7. A compound according to claim 6 , wherein X 1 is heteroaryl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

8. A compound according to claim 7 , wherein X 1 is furyl, thienyl, pyrrolyl, thiazolyl, imidazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyridyl or pyrimidinyl, each of which is optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

9. A compound according to claim 8 , wherein X 1 is pyridyl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

10. A compound according to claim 1 , wherein X 2 is arylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

11. A compound according to claim 10 , wherein X 2 is phenylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

12. A compound according to claim 11 , wherein X 2 is phenylene.

13. A compound according to claim 1 , wherein X 2 is heteroarylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

14. A compound according to claim 13 wherein X 2 is furylene, thienylene, pyrrolylene, thiazolylene, imidazolylene, oxazolylene, isoxazolylene, isothiazolylene, pyridylene or pyrimidinylene, each of which is optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

15. A compound according to claim 1 , wherein X 3 is aryl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

16. A compound according to claim 15 , wherein X 3 is aryl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

17. A compound according to claim 15 , wherein X 3 is phenyl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

18. A compound according to claim 17 , wherein X 3 is phenyl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

19. A compound according to claim 1 , wherein X 3 is heteroaryl optionally substituted with one or more substituents selected from

halogen, hydroxy; or

20. A compound according to claim 19 , wherein X 3 is heteroaryl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

21. A compound according to claim 20 , wherein X 3 is furyl, thienyl, pyrrolyl, thiazolyl, imidazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyridyl or pyrimidinyl, each of which is optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

22. A compound according to claim 21 wherein X 3 is pyridyl optionally substituted with one or more substituents selected from C 1-6 -alkyl, phenyl, C 1-6 -alkylsulfonyl, C 1-6 -alkylaminocarbonyl or C 1-6 -dialkylaminocarbonyl each of which is optionally substituted with one or more halogens.

23. A compound according to claim 1 , wherein X 4 is arylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

24. A compound according to claim 23 , wherein X 4 is phenylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

25. A compound according to claim 24 , wherein X 4 is phenylene.

26. A compound according to claim 1 , wherein X 4 is heteroarylene optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

27. A compound according to claim 26 wherein X 4 is furylene, thienylene, pyrrolylene, thiazolylene, imidazolylene, oxazolylene, isoxazolylene, isothiazolylene, pyridylene or pyrimidinylene, each of which is optionally substituted with one or more substituents selected from

halogen or

C 1-6 -alkyl optionally substituted with one or more halogens.

28. A compound according to claim 1 , wherein Ar is phenylene which is optionally substituted with one or more substituents selected from

halogen, hydroxy or cyano; or

29. A compound according to claim 28 , wherein Ar is phenylene which is optionally substituted with one or more substituents selected from

halogen; or

C 1-6 -alkyl, C 1-6 -alkoxy, aryloxy, aralkoxy or phenyl, each of which is optionally substituted with one or more halogens.

30. A compound according to claim 28 , wherein Ar is phenylene which is optionally substituted with methyl or trifluoromethyl.

31. A compound according to claim 30 , wherein Ar is phenylene.

32. A compound according to claim 1 , wherein Y 1 is S.

33. A compound according to claim 1 , wherein Y 1 is O.

34. A compound according to claim 1 , wherein Y 2 is O.

35. A compound according to claim 1 , wherein Y 2 is S.

36. A compound according to claim 1 , wherein n is 1.

37. A compound according to claim 1 , wherein R 1 is hydrogen or a substituent selected from C 1-6 -alkyl, aralkyl, C 1-6 -alkoxy, aryloxy, aralkoxy each of which is optionally substituted with one or more halogens.

38. A compound according to claim 37 , wherein R 1 is hydrogen or a substituent selected from C 1-6 -alkyl, C 1-6 -alkoxy each of which is optionally substituted with one or more halogens.

39. A compound according to claim 38 , wherein R 1 is hydrogen.

40. A compound according to claim 1 , wherein R 2 is hydrogen.

41. A compound according to claim 1 , which is selected from the following:

[4-(3,3-Bis-biphenyl-4-yl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid, {4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid, and {4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid, or

a salt thereof with a pharmaceutically acceptable acid or base, optical isomer or mixture of optical isomers, racemic mixture, or tautomeric forms thereof.

42. A compound according to claim 1 , which is selected from the following:

[4-(3,3-Bis-biphenyl-4-yl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-allyloxy)-2-methyl-phenoxy]-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-fu ran-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yd)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-tert-butyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid, {4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yd)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yd)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-tert-butyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yd)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yd)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-allylsulfanyl)-phenoxy]-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-allyloxy)-phenoxy]-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-fu ran-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(-furan-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-phenoxy)-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-tert-butyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-allylsulfanyl)-phenoxy]-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-allylsulfanyl}-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-allyloxy}-phenoxy)-acetic acid

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-phenoxy)-acetic acid

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-phenoxy)-acetic acid

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allyloxy]-phenoxy}acetic acid

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-phenoxy}-acetic acid

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-tert-butyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-allyloxy]-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-allylsulfanyl]-phenoxy}-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-2-ethyl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-2-ethyl-allyloxy)-2-methyl-phenoxy]-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-tert-butyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-2-ethyl-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-fu ran-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-fu ran-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-tert-butyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethyl-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethyl-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-2-ethoxy-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-2-ethoxy-allyloxy)-2-methyl-phenoxy]-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-dimethylcarbamoyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-tert-butyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-2-ethoxy-allylsulfanyl)-2-methyl-phenoxy]-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-methyl-furan-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-chloro-thiophen-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl] 2-ethoxy-allyloxy}-2-methyl-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(4-acetyl-thiophen-2-yl)-phenyl]-2-ethoxy-allylsulfanyl}-2-methyl-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-trifluoromethyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-tert-butyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-acetyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-phenoxy-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-isopropyl-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,4′-difluoro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′,5′-dichloro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethoxy-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(2′-chloro-4′-fluoro-biphenyl-4-yl)-2-ethoxy-allylsulfanyl]-2-methyl-phenoxy}-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-allylsulfanyl)-2-chloro-phenoxy]-acetic acid,

[4-(3,3-Bis-biphenyl-4-yl-allyloxy)-2-chloro-phenoxy]-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-allyloxy}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(-furan-2-yl)-phenyl]-allyloxy}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-methyl-furan-2-yl)-phenyl]-allylsulfanyl}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(furan-2-yl)-phenyl]-allylsulfanyl}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-chloro-thiophen-2-yl)-phenyl]-allyloxy}-2-chloro-phenoxy)-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-thiophen-2-yl-phenyl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allylsulfanyl}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-allyloxy}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allyloxy}-2-chloro-phenoxy)-acetic acid,

(4-{3,3-Bis-[4-(5-acetyl-thiophen-2-yl)-phenyl]-2-ethyl-allylsulfanyl}-2-chloro-phenoxy)-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-methylsulfanyl-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-amino-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-amino-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4-pyridin-2-yl-phenyl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methanesulfonyl-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methoxy-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethoxy-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-methyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-trifluoromethyl-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-chloro-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-tert-butyl-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

[4-(3,3-Bis-[1,1′;4′,1″]terphenyl-4-yl-allylsulfanyl)-2-chloro-phenoxy]-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-acetyl-biphenyl-4-yl)-allyloxy]-2-methyl-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-phenoxy-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(4′-isopropyl-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,4′-difluoro-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′,5′-dichloro-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid,

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allyloxy]-2-chloro-phenoxy}-acetic acid, and

{4-[3,3-Bis-(3′-chloro-4′-fluoro-biphenyl-4-yl)-allylsulfanyl]-2-chloro-phenoxy}-acetic acid, or

a salt thereof with a pharmaceutically acceptable acid or base, optical isomer or mixture of optical isomers, racemic mixture, or tautomeric forms thereof.

43. A compound according to claim 1 , which is a PPARδ agonist.

44. A compound according to claim 43 , which is a selective PPARδ agonist.

45. A pharmaceutical composition comprising, as an active ingredient, at least one compound according to claim 1 together with one or more pharmaceutically acceptable carriers or excipients.

46. A pharmaceutical composition according to claim 45 in unit dosage form, comprising from about 0.05 mg to about 1000 mg per day of the compound.

47. A pharmaceutical composition according to claim 46 for oral, nasal, transdermal, pulmonal, or parenteral administration.

48. A method for the treatment of conditions mediated by the Peroxisome Proliferator-Activated Receptors (PPAR), wherein the condition is selected from type I diabetes, type II diabetes, impaired glucose tolerance (IGT), insulin resistence, dyslipidemin, Syndrome X, hypertension, obesity, hyperglyccmia, atherloselerosis, hyperlipidemia, coronary artery disease, myocardial ischemia, glomerulonephritis, glomeruloselerosis, nephritic syndrome, hypertensive nephrosclerosis, diabetic complications, loss of cognative function in dementia, psoriasis, Polycystic Ovarian Syndrome (PCOS), osteoporosis, progression from IGT to type II diabetes, and progression from non insulin-requiring type II diabetes to insulin-requiring type II diabetes, the method comprising administering to a subject in need thereof an effective amount of a compound according to claim 1 or a pharmaceutical composition comprising the same.

49. A method for the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance or obesity, the method comprising administering to a subject in need thereof an effective amount of a compound according to claim 1 or of a pharmaceutical composition comprising the same.

50. The method according to claim 48 wherein the effective amount of the compound is in the range of from about 0.05 mg to about 1000 mg per day.

51. The method according to claim 49 wherein the effective amount of the compound is in the range of from about 0.05 mg to about 1000 mg per day.

52. A pharmaceutical composition according to claim 45 in unit dosage form, comprising from about 0.05 mg to about 1000 mg per day of the compound.

53. A pharmaceutical composition according to claim 45 in unit dosage form, comprising from about 0.5 mg to about 200 mg per day of the compound.

54. The method according to claim 48 wherein the effective amount of the compound is in the range of from about 0.1 to about 500 mg per day.

55. The method according to claim 48 wherein the effective amount of the compound is in the range of from about 0.5 mg to about 200 mg per day.

56. The method according to claim 49 wherein the effective amount of the compound is in the range of from about 0.1 to about 500 mg per day.

57. The method according to claim 49 wherein the effective amount of the compound is in the range of from about 0.5 mg to about 200 mg per day.

Assignments (2)

NOTICE OF RELEASE OF SECURITY INTEREST IN PATENTS FOR REEL/FRAME 030982/0793 Recorded Apr 7, 2014

From: M&F TTP HOLDINGS LLC

To: HIGH POINT PHARMACEUTICALS, LLC

Reel/Frame 032621/0867 →

SECURITY AGREEMENT Recorded Aug 9, 2013

From: HIGH POINT PHARMACEUTICALS, LLC

To: M&F TTP HOLDINGS LLC C/O MACANDREWS & FORBES HOLDINGS INC.

Reel/Frame 030982/0793 →