Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them

1. A compound of the fommia (I′)

wherein

A is

R 18 , R 19 and R 20 are independently selected from the group consisting of hydrogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, R 21 and R 22 are independently selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms, or R 21 and R 22 form together with the nitrogen atom an optionally substituted heterocycle having 4 to 7 members and 1 to 3 heteroatoms including the already present nitrogon atom, the additional heteroatoms being-independently selected from the group consisting of O, N or furthermore R 21 is selected from the group consisting of alkylsulfonyl, alkylsulfoxide and alkylcarbonyl and then R 22 is hydrogen,

B is thiophenyl,

X is selected from the group consisting of a bond or —CO—NR 36 —,

Y is selected from the group consisting of a bond, —(CH 2 ) n —, —(CH 2 ) r -Q-(CH 2 ) s — and thiazolidine,

Q is selected from the group consisting of pinerazine, homopiperazine, 2-methylpiperazine, 2,5-dimethylpiperazine, piperidine, 1,2,3,6-tetrahydropyridine, pyrrolidine, azetidine, thiazolidine and a saturated carbon ring having 3 to 7 members,

Φ is —(CH 2 ) p —NR 37 —(CH 2 ) q —,

R 36 and R 37 are independently selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and —CO—R 38 , R 38 is alkyl or alkoxy of 1 to 6 carbon atoms,

R 39 is hydrogen,

m, n, p, q, r and s are independently integers from 0 to 6, and its pharmaceutically acceptable salts.

2. A compound of claim 1 selected from the group consisting of

2-amino-N-(4-{[amino(2-thienyl)methylidene]amino}phenethyl)-5-methoxybenzamide;

5-amino-N-(4-{[amino(2-thienyl)methylidene]amino}phenethyl)-2-hydroxybenzamide;

4-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-[4-[(methylsulphonyl)amino]phenyl}butanamide;

4-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-[4-(dimethylamino)phenyl]butanamide;

5-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-[4-(dimethylamino)phenyl]pentanamide;

(AR)-2-(3-{[amino(2-thienyl)methylidene]amino}phenyl)-N-[4-(dimethylamino)phenyl]-1,3-thiazolidine-4-carboxamide;

tert-butyl 3-{[amino(2-thienyl)methylidene]amino}benzyl(3-[4-(dimethylamino)anilino]-3-oxopropyl}carbamate;

3-[(3-{[amino(2-thienyl)methylidene]amino}-benzyl)amino]-N-[4-(4-methyl-1-piperazinyl)phenyl]propanamide;

3-[(3-{[amino(2-thienyl)methylidene]amino}-benzyl)amino]-N-[4-(4-morpholinyl)phenyl]propanamide;

N′-[4-(2-{[5-(dimethylamino)-2-hydroxybenzyl]amino}ethyl)phenyl]-2-thiophenecarboximidamide;

N-(4-{[(4-{[amino(2-thienyl)methylidone]amino)phenethyl)amino]methyl}phenyl)acetamide;

N′-[4-(2-{[5-(dimethylamino)-2-hydroxy-3-methoxybenzyl]amino}-ethyl)phenyl]-2-thiophenecarboximidamide;

N′-[4-(2-{([4-(dimethylamino)anilino]carbonyl}amino)-ethyl]phenyl}-2-thiophenecarboximidamide;

N′-[4-(2-{[5-(dimethylamino)-2-hydroxy-3-methoxybenzyl]-(methyl)amino]ethyl}phenyl)-2-thiophenecarboximidamide;

and the pharmaceutically acceptable salts of the latter.