IP Library Granted Patent US 9,271,676
Granted Patent B2
US 9,271,676 · App. 10/670,144 · Granted Mar 1, 2016

Method for measuring of edema

Inventors: Esko Alanen (Savonlinna, FI); Aulis Tapani Lahtinen (Kuopio, FI); Jouni Nuutinen (Kuopio, FI)
Assignee: Delfin Technologies Ltd.
A61B5/4878A61B5/0531A61B5/0537
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,271,676
App. No.
10/670,144
Granted
Mar 1, 2016
Kind
B2
Abstract

The invention relates to a method for measuring tissue edema. By a method in accordance with the invention an electromagnetic probe ( 24 ) is placed on the skin, and the capacitance of the probe is proportional to the dielectric constant of the skin and subcutaneous fat, which is proportional to the water content of the skin. The edema is scored by measuring the capacitance of the electromagnetic probe, so called open-ended coaxial cable, at a high frequency, approximately 20-500 MHz.

Claims (44)

1. A method for measuring tissue edema, comprising:

placing an open-ended coaxial probe on a skin surface;

transmitting an electromagnetic field through the skin surface;

measuring a capacitance of the probe, wherein the measured capacitance of the probe is proportional to a dielectric constant of skin tissue and subcutaneous fat tissue, which is further proportional to a water content of the skin tissue and the subcutaneous fat tissue, the probe having two concentric electrodes separated by a distance configured such that the electromagnetic field penetrates past the skin tissue to the subcutaneous fat tissue underneath the skin tissue, wherein said distance is 6 mm to 10 mm, wherein said distance is along a radial direction, wherein the two concentric electrodes comprise an inner electrode and outer electrode, and wherein said distance is from an outer edge of the inner electrode to an inner edge of the outer electrode;

scoring the edema by measuring the capacitance of the probe at a frequency of 20-500 MHz.

2. A method according to claim 1 , in which

the measurement is made manually and takes between one and ten seconds.

3. A method according to claim 1 , in which

for the measurement the probe is secured on the skin surface by a strap attachment, for hours or days, in which case the edema can be monitored continuously.

4. A method according to claim 1 , in which

the edema of an upper part of a dermis is measured using a frequency of 20-50 MHz, in which case an electric field is concentrated in the upper part of the dermis.

5. A method according to claim 1 , in which

the edema of a lower part of a dermis and the underlying subcutaneous fat tissue is measured using a frequency of 50-500 MHz, in which case an electric field penetrates deeply into the lower part of the dermis and the underlying subcutaneous fat tissue.

6. A method according to claim 1 wherein a measured value of the edema is based, at least partially, on the dielectric constant of the subcutaneous fat tissue.

7. A method according to claim 1 wherein the measuring of the capacitance of the probe at the high frequency further comprises measuring the edema of a dermis.

8. A method according to claim 1 wherein the tissue edema of a dermis and of the underlying subcutaneous fat tissue is measured.

9. A method according to claim 1 wherein the two electrodes of the open-ended coaxial probe comprise an outer electrode and an inner electrode, wherein the outer electrode comprises a circular shape, wherein the inner electrode comprises a circular shape, wherein the outer electrode surrounds the inner electrode, wherein an insulator is between the outer electrode and the inner electrode, wherein the insulator surrounds the inner electrode, and wherein the distance between the inner electrode and the outer electrode is 7-10 mm.

10. A method as in claim 1 wherein the open-ended coaxial probe comprises a single open-ended coaxial probe, and wherein the electromagnetic field penetrates through skin layers including a dermis, wherein the electric field further penetrates beyond the skin layers and penetrates into the subcutaneous fat tissue, wherein a phase difference of a reflected electromagnetic field is measured, and wherein a water content of the skin corresponds to the phase difference.

11. A device for measuring tissue edema, which device includes

an open-ended coaxial probe configured to be placed on a skin surface during the measurement wherein a capacitance of the probe is proportional to a dielectric constant of the skin tissue and subcutaneous fat tissue, which is further proportional to a water content of the skin tissue and the subcutaneous fat tissue,

a plurality of high frequency components configured to measure the capacitance of the probe, wherein the plurality of high frequency components are arranged to measure the capacitance of the probe at a first range of 20-50 MHz, wherein the first range corresponds to a measure of an upper part of a dermis,

wherein the plurality of high frequency components are arranged to measure the capacitance of the probe at a second range of 50-500 MHz, and wherein the second range corresponds to a measure of a lower part of the dermis and the subcutaneous fat tissue,

a calculating unit configured to calculate the dielectric constant and the tissue edema, and

the probe having two concentric electrodes separated by a distance, the distance between the two electrodes of the probe configured such that the electromagnetic field penetrates past the skin tissue and into the subcutaneous fat tissue, wherein said distance is 6 mm to 10 mm, wherein said distance is along a radial direction, wherein the two concentric electrodes comprise an inner electrode and outer electrode, and wherein said distance is from an outer edge of the inner electrode to an inner edge of the outer electrode.

12. A device according to claim 11 , in which the device is arranged to measure only on a single precisely set frequency.

13. A device according to claim 11 , in which the high frequency unit comprises an oscillator, a power splitter, and an attenuator connected between the oscillator and the power splitter, wherein attenuator is configured to prevent access of a signal reflected from the electromagnetic probe.

14. A device according to claim 13 wherein attenuator is configured to prevent access of a signal reflected from the electromagnetic probe to an amplifier, and wherein under the influence of the amplifier the signal reflected from the electromagnetic probe goes twice through the attenuator when propagating to an input of the amplifier.

15. A device according to claim 11 wherein a measured value of the tissue edema is based, at least partially, on the dielectric constant of the subcutaneous fat tissue.

16. A device according to claim 11 wherein the high frequency unit is configured to measure the capacitance of the probe at the first range of 20-50 MHz and at the second range of 50-500 MHz for measuring the tissue edema of the upper part of the dermis, and the lower part of the dermis and the subcutaneous fat tissue, respectively.

17. A device according to claim 11 wherein the device is configured to measure the tissue edema of the dermis and of the underlying subcutaneous fat tissue.

18. A device according to claim 11 wherein the two electrodes of the open-ended coaxial probe comprise a first electrode and a second electrode, wherein the first electrode comprises a circular shape, wherein the second electrode comprises a circular shape, wherein the first electrode surrounds the second electrode, wherein an insulator is between the first electrode and the second electrode, wherein the insulator surrounds the second electrode, and wherein said distance between the first electrode and the second electrode is 8-10 mm.

19. A method for measuring tissue edema comprising:

placing an open-ended coaxial probe on a skin surface, wherein the probe comprises two electrodes, wherein the two electrodes are concentric, wherein a distance separating the two electrodes of the probe is 6-10 mm, wherein said distance is along a radial direction, wherein the two concentric electrodes comprise an inner electrode and outer electrode, and wherein said distance is from an outer edge of the inner electrode to an inner edge of the outer electrode;

generating a first signal from an oscillator, wherein a frequency of the first signal is 20 to 500 MHz;

transmitting a first portion of the first signal to the probe and through the skin tissue and subcutaneous fat tissue;

receiving a reflected signal from the skin tissue and subcutaneous fat tissue through the probe;

leading the reflected signal to a first input of a phase detector;

transmitting a second portion of the first signal to a second input of the phase detector,

operating the phase detector in a saturated state, wherein signal amplitudes from the reflected signal and the second portion of the first signal form the saturated state;

measuring a phase difference between the reflected signal and the second portion of the signal;

calculating a dielectric constant from the phase difference;

calculating a water content of the skin tissue and the subcutaneous fat tissue based on the dielectric constant; and

detecting edema based on, at least partially, the water content.

20. A method according to claim 19 wherein the two electrodes of the open-ended coaxial probe comprise an outer electrode and an inner electrode, wherein the outer electrode comprises a circular shape, wherein the inner electrode comprises a circular shape, wherein the outer electrode surrounds the inner electrode, wherein an insulator is between the outer electrode and the inner electrode, wherein the insulator surrounds the inner electrode, and wherein the insulator has a thickness of 7-10 mm.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2004
From: ALANEN, ESKO; LAHTINEN, AULIS TAPANI; NUUTINEN, JOUNI
To: DELFIN TECHNOLOGIES LTD.
Reel/Frame 015340/0802 →
Priority Claims (1)
FI 20010601 · Mar 23, 2001 · national
Continuity (2)
Continuation In Part PCTFI0200234 · Mar 21, 2002
Related Publication 20050177061A1 · Aug 11, 2005