IP Library Granted Patent US 7,488,742
Granted Patent B2
US 7,488,742 · App. 10/671,216 · Granted Feb 10, 2009

Thrombin receptor antagonists

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Quick Facts
Patent No.
US 7,488,742
App. No.
10/671,216
Granted
Feb 10, 2009
Kind
B2
Abstract

A series of compounds represented by the structural formulas and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and binders to cannabinoid receptors.

Claims (29)

1. A compound represented by any of the following structural formulas

or a pharmaceutically acceptable salt thereof.

2. A composition comprising at least one compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

3. A compound represented by the following structural formula:

or a pharmaceutically acceptable salt thereof.

4. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

5. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

6. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

7. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

8. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

9. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

10. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

11. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

12. A compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof.

13. A composition comprising a compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

14. A composition comprising a compound represented by the following structural formula

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

15. A composition comprising a compound represented by the following structural formula

or a pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier.

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 12, 2020
From: ARALEZ PHARMACEUTICALS TRADING DAC
To: TOPROL ACQUISITION LLC
Reel/Frame 054027/0047 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2020
From: TOPROL ACQUISITION LLC
To: XSPIRE PHARMA, LLC
Reel/Frame 053731/0376 →
RECEIVING PARTY/ASSIGNEE ADDRESS CHANGE FOR ASSIGNMENT RECORDED AT REEL/FRAME 039767/0695 Recorded Aug 31, 2018
From: MERCK SHARP & DOHME CORP.
To: ARALEZ PHARMACEUTICALS TRADING DAC
Reel/Frame 046989/0669 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY PREVIOUSLY RECORDED AT REEL: 046696 FRAME: 0772. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 30, 2018
From: ARALEZ PHARMACEUTICALS TRADING DESIGNATED ACTIVITY COMPANY
To: DEERFIELD MANAGEMENT COMPANY, L.P., AS ADMINISTRATIVE AGENT
Reel/Frame 046988/0741 →
SECURITY INTEREST Recorded Aug 24, 2018
From: ARALEZ PHARMACEUTICAL TRADING DAC
To: DEERFIELD MANAGEMENT COMPANY, L.P., AS ADMINISTRATIVE AGENT
Reel/Frame 046696/0772 →
SECURITY INTEREST Recorded Sep 29, 2016
From: ARALEZ PHARMACEUTICALS TRADING DAC
To: DEERFIELD PRIVATE DESIGN FUND III, L.P.; DEERFIELD INTERNATIONAL MASTER FUND, L.P.; DEERFIELD PARTNERS, L.P.
Reel/Frame 039892/0309 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2016
From: MERCK SHARP & DOHME CORP.
To: ARALEZ PHARMACEUTICALS TRADING DAC
Reel/Frame 039767/0695 →
CHANGE OF NAME Recorded Aug 30, 2012
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 028884/0151 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 6, 2005
From: CHACKALAMANNIL, SAMUEL; CHELLIAH, MARIAPPAN V.; XIA, YAN
To: SCHERING CORPORATION
Reel/Frame 015553/0423 →