Cyclodextrin-based materials, compositions and uses related thereto
View Patent ↗This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.
1. A polymer composition comprising:
a linear biocompatible polymer including a plurality of inclusion hosts,
linking molecules, each linking molecule comprising a PEG moiety and at least two adamantane moieties that form inclusion complexes with the inclusion hosts, and
at least one therapeutic agent,
wherein the linking molecules cross-link the polymer solely through inclusion complexes; and
wherein the therapeutic agent is covalently attached to an adamantane moiety.
2. The polymer composition of claim 1 , wherein the inclusion hosts are cyclodextrin moieties.
3. The polymer composition of claim 1 , wherein the therapeutic agent is a nucleic acid.
4. The polymer composition of claim 3 , wherein the nucleic acid is provided in a delivery system selected from a virus, a polymer, and a liposome.
5. The polymer composition of claim 1 , wherein the therapeutic agent is a protein, a polypeptide, or a small organic molecule.
6. The polymer composition of claim 1 , wherein the therapeutic agent is a protein or polypeptide.
7. The polymer composition of claim 1 , further comprising at least one adjuvant.
8. The polymer composition of claim 1 , further comprising an adjuvant that increases the effectiveness of the therapeutic agent.
9. The polymer of claim 1 , wherein the linking molecules cross-link the polymer intramolecularly.
10. The polymer of claim 1 , wherein the linking molecules cross-link the polymer intermolecularly.
11. The polymer composition of claim 2 , wherein the cyclodextrin moieties are within the polymer chain.
12. The polymer composition of claim 2 , wherein the cyclodextrin moieties are appended to the polymer chain.
13. The polymer composition of claim 1 , wherein the linear biocompatible polymer is biodegradable.
14. The polymer composition of claim 1 , wherein the linking molecule comprises at least three adamantane moieties.