Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same
The present invention relates to an isothiazole derivative of the following formula 1 or nontoxic salt thereof: wherein, R 1 is hydrogen, alkoxy group or halogen group; R 2 is methyl or amino group. According to the present invention, isothiazole derivative or nontoxic salt thereof having antipyretic, analgesic and antiphlogistic activity and an improved side effect; process for the preparation thereof; and pharmaceutical composition including the same can be provided.
1. An isothiazole derivative of the formula 1 or nontoxic salt thereof:
wherein, R 1 is hydrogen, alkoxy or halogen; and R 2 is methyl or amino group.
2. The isothiazole derivative or nontoxic salt thereof according to claim 1 , wherein said isothiazole derivative is selected from a group consisting of:
4-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)-5-methyl-isothiazol,
4-(5-methyl-3-phenyl-isothiazole-4-yl)-benzonesulfonamide,
4- [3-(4-bromophenyl)-5-methyl-isothiazIole-4-yl]-benzenesulfonamide,
4-[3-(4-methoxyphenyl)-5-methyl-isothiazole-4-yl]-benzenesulfonamide,
4-[3-(4-fluorophenyl)-5-methyl-isothiazole-4-yl]-benzenesulfonamide,
4-(4-methanesulfonylphenyl)-5-methyl-3-phenyl-isothiazole,
3-(4-bromophenyl)4-(4-methanesulfonylphenyl)-5-methyl-isotiazole,
3-(4-methoxyphenyl)-4-(4-methanesulfonylphenyl)-5-methyl-isothiazole, and
3-(4-fluorophenyl)-4-(4-methanesulfonylphenyl)-5-methyl-isothiazole.
3. A pharmaceutical composition with antipyretic, analgesic and antiphiogistic activity, including a therapeutically effective amount of an isothiazole derivative or nontoxic salt thereof according to claim 1 or 2 as an effective component and a pharmaceutically acceptable carrier.