Pharmaceutical-grade ferric citrate
View Patent ↗The present invention relates to pharmaceutical-grade ferric citrate. Pharmaceutical-grade ferric citrate contains a definite composition and a definite hydrate. The present invention also relates to a method using a solid—solid reaction to produce pharmaceutical-grade ferric citrate. The present invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of pharmaceutical-grade ferric citrate and a food comprising pharmaceutical-grade ferric citrate.
1. A method for preparing ferric citrate comprising:
mixing solid citric acid with a solid ferric salt to form a mixture;
adding alcohol to the mixture; and
filtering the mixture to obtain solid ferric citrate.
2. The method as claimed in claim 1 , which further comprises drying said solid ferric citrate by heat.
3. The method as claimed in claim 2 , wherein said solid ferric citrate is dried at 30° C. to 120° C.
4. The method as claimed in claim 1 , which further comprises purifying said solid ferric citrate by mixing with alcohol and filtering the mixture one or more times.
5. The method as claimed in claim 4 , which further comprises drying said solid ferric citrate by heat.
6. The method as claimed in claim 5 , wherein said solid ferric citrate is dried at 30° C. to 120° C.
7. The method as claimed in claim 1 , wherein the ferric salt is ferric chloride, ferric sulfate or ferric nitrite.
8. The method as claimed in claim 1 , wherein the obtained ferric citrate is fixed in molecular structure and contains a definite mean number of water molecules.