Compounds for the treatment of metabolic disorders
View Patent ↗Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
1. A compound of the formula:
wherein
n is 1 or 2;
t is 0 or 1;
m is 0 and r is 1, or m is 1 and r is 0;
A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or
cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are mono-substituted by methyl or ethyl; or
a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula II by a ring carbon; and
Z is
2. The compound of claim 1 , wherein A is cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or both of the ring carbons adjacent to the remainder of the compound of formula II are mono-substituted by methyl or ethyl.
3. The compound of claim 1 , wherein A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: fluoro, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy.
4. The compound of claim 3 , of the formula:
wherein
m is 0 or 1;
r is 0 or 1;
Z is
and R 3 is hydrogen or halo.
5. The compound of claim 4 , being 3-(2-(4-(2,6-difluorobenzyloxy)phenyl)-2-oxoethyl)thio-1H-1,2,4-triazole.