Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals
View Patent ↗The present invention provides an effective method and composition for the prevention, amelioration or control of external parasites on a human or animal via the administration of a prophylactically, therapeutically or pharmaceutically effective amount of a neuronal sodium channel antagonist to a human or animal in need thereof.
1. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 20% w/v of a neuronal sodium channel antagonist which is a compound of the formula:
together with about 10% w/v of amitraz, about 20% w/v of isopropyl myristate and about 10% cineole in diethyl toluamide, wherein each w/v % indicates weight in relation to the total volume of the composition.
2. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 20% w/v of a neuronal sodium channel antagonist which is a compound of the formula:
together with about 10% w/v of amitraz, in isopropyl myristate, wherein each w/v % indicates weight in relation to the total volume of the composition.
3. An ectoparisiticidal composition which comprises a pharmaceutically acceptable carrier and about 30% w/v of:
amitraz and a neuronal sodium channel antagonist which is a compound of the formula:
wherein the about 30% w/v is the combined weight of amitraz and the neuronal sodium channel antagonist in relation to the total volume of the composition.
4. The ectoparisiticidal composition of claim 3 , further comprising diethyl toluamide.
5. The ectoparasiticidal composition of claim 3 , further comprising cineole.
6. The ectoparasiticidal composition of claim 5 , wherein the cineole is present at about 10% w/v in relation to the total volume of the composition.
7. The ectoparasiticidal composition of claim 3 , wherein the carrier comprises a lower alkyl ketone or an ester.
8. The ectoparasiticidal composition of claim 7 , wherein the lower alkyl ketone or the ester is present at about 30% to about 60% w/v in relation to the total volume of the composition.
9. The ectoparasiticidal composition of claim 3 , wherein the carrier comprises a spreading agent.
10. The ectoparasiticidal composition of claim 3 , wherein the spreading agent is isopropyl myristate.