Ethers of O-desmethyl venlafaxine
View Patent ↗This invention provides O-α-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimehtylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): wherein the variables R 1 and R 2 are defined herein, and where the configuration at the steriogenic center (*) may be R, S, or RS (the racemate).
1. A compound of the Formula (I):
wherein:
the configuration at the steriogenic center (*) may be R, S, or RS (the racemate);
R 1 is C 1 –C 6 alkoxy; and
R 2 is selected from H, or C 1 –C 6 alkyl; or, pharmaceutically acceptable salt or hydrate thereof.
2. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of Formula I:
wherein:
the configuration at the steriogenic center (*) may be R, S, or RS (the racemate);
R 1 is C 1 –C 6 alkoxy; and
R 2 is selected from H, or C 1 –C 6 alkyl; or, pharmaceutically acceptable salt or hydrate thereof; and a pharmaceutically acceptable carrier or excipient.