Rehydration composition
View Patent ↗The invention relates to a fluid that can be used for preventing or treating hypohydration and the secondary consequences thereof. The fluid comprises one or more carbohydrates and minerals and is further characterized by a low osmolarity. The invention further relates to the use of such a fluid for medical, dietetic and other applications.
1. A fluid for treating hypohydration, comprising at least one methyl amine, one or more digestible carbohydrates and one or more minerals, wherein
the methyl amine is selected from dimethylglycine and sarcosine with the amount of methyl amine being between 0.2-10 g/l,
the digestible carbohydrate is in the amount of between 20-75 g/l,
the mineral includes at least one of calcium and magnesium, and said fluid has an essentially hypotonic osmolarity in the range of 70 to 275 mOsm/l,
and wherein the fluid treats hypohydration when administered to a subject in need thereof.
2. A fluid according to claim 1 , comprising more than two different types of monosaccharide units.
3. A fluid according to claim 1 , having a dry mass content of 9 wt. % or less.
4. A fluid according to claim 1 , wherein the digestible carbohydrate concentration is between 10 and 80 g/l.
5. A fluid according to claim 1 , wherein at least part of the digestible carbohydrates is formed by polysaccharides comprising glucose and wherein at least 0.5 g/l of the digestible carbohydrates is ribose or inositol.
6. A fluid according to claim 1 , wherein the one or more carbohydrates have an average chain length in the range of 3-50 monosaccharide units.
7. A fluid according to claim 1 , wherein at least 50 wt. % of the carbohydrate content is in the form of one or more of oligosaccharides or polysaccharides.
8. A fluid according to claim 1 , wherein the one or more carbohydrates are selected from the group consisting of glucose, fructose, galactose, mannose, ribose and inositol.
9. A fluid according to claim 8 , comprising glucose, fructose, and mannose, and wherein fructose and mannose together are present in an amount between 0.05-0.6 mole per mole glucose.
10. A fluid according to claim 1 , wherein the one or more carbohydrates comprise at least 0.5 g/l ribose, at least 0.5 g/l inositol and/or at least 0.5 g/l galactose.
11. A fluid according to claim 1 , wherein the mineral concentration is between 0.1 and 30 g/l.
12. A fluid according to claim 1 , further including one or more minerals selected from the group consisting of sodium, potassium, chloride, phosphate, zinc, iron and copper.
13. A fluid according to claim 1 , wherein the magnesium concentration is 100 mg/l or more.
14. A fluid according to claim 12 , wherein the zinc concentration is 10 mg/l or more.
15. A fluid according to claim 1 , wherein the calcium concentration is 300 mg/l or more.
16. A fluid according to claim 12 , wherein the iron concentration is 5 mg/l or more.
17. A fluid according to claim 1 , comprising glycerol, lipoic acid, a vitamin, citrate, phosphate, malate, taurine, caffeine or a combination thereof.
18. A fluid according to claim 17 , comprising tocopherol.
19. A fluid according to claim 17 , wherein glycerol is present in a concentration of 0.1-20 g/l.
20. A fluid according to claim 17 , wherein lipoic acid is present in a concentration of at least 20 mg/l.
21. A fluid according to claim 17 , wherein taurine is present in a concentration of 0.1-2 g/l and wherein citrate is present in a concentration of 0.2-2 g/l.
22. A fluid according to claim 17 , wherein caffeine is present in a concentration of 0.1-1 g/l.
23. A fluid according to claim 1 , comprising methionine.
24. A fluid according to claim 1 , having a pH in the range of 2.5-6.8.
25. A fluid according to claim 1 , having a nitrogen content of less than 3 g/l.
26. A fluid according to claim 1 , in the form of a water solution, a fruit juice, a whey dairy drink, a beverage, or a fluid for tube or enteric administration.
27. Concentrate for preparation of a fluid according to claim 1 .
28. Concentrate according to claim 27 , in the form of a pre-mix, a powder, an agglomerate, a fluid, a syrup, a gel, a tablet or a capsule.
29. A composition according to claim 1 ,
wherein the one or more minerals are present in an amount between about 1.5 and about 15 g/l,
wherein the one or more carbohydrates are selected from the group consisting of galactose, ribose, inositol and mannose present in a concentration of at least about 0.5 g/l, and
wherein the composition has a nitrogen content of less than about 3 g/l.
30. A composition according to claim 1 , wherein the fluid is for treating an ill subject.
31. A composition according to claim 30 , wherein the ill subject is a subject suffering from hypohydration selected from the group consisting of a subject that used a drug having a diuretic action, a subject having a spinal cord injury, a subject in a coma, a subject who is confined to bed, and a subject having a kidney dysfunction.