Aluminum-zirconium antiperspirant salts with low M:CI ratio
View Patent ↗Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions that have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. These salts also typically exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
1. An aluminum-zirconium tetrachlorohydrate having a metal (Al+Zr) to chloride molar ratio of 0.90 to 1.00.
2. An aluminum-zirconium tetrachlorohydrate having the formula Al n Zr(OH) [3n+4−m(n+1)] (Cl) [m(n+1)] -(Gly) q wherein n is 2 to 6, m is 1.00 to 1.11, and q is about 0.8 to about 4.0.
3. The aluminum-zirconium tetrachlorohydrate of claim 2 wherein q is about 1.0 to 2.0.
4. The aluminum-zirconium tetrachlorohydrate of claim 2 wherein m is about 1.02 to about 1.11.
5. The aluminum-zirconium tetrachlorohydrate of claim 2 wherein m is about 1.04 to about 1.11.
6. The aluminum-zirconium tetrachlorohydrate of claim 2 which, when analyzed by HPLC as a 10% aqueous solution using conditions capable of resolving the aluminum into at least four successive peaks (labeled peaks 2 to 5), exhibits an HPLC peak 5 area of at least 45% and an HPLC peak 4 to peak 3 area ratio of at least 0.4, wherein substantially all of the aluminum is found in peaks 3, 4 and 5.
7. The aluminum-zirconium tetrachlorohydrate of claim 2 made with a zirconium hydroxychloride of the formula Zr(OH) 4−b Cl b wherein b is 2.2 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.45 and 0.25.
8. The aluminum-zirconium tetrachlorohydrate of claim 1 made with a zirconium hydroxychloride of the formula Zr(OH) 4−b Cl b wherein b is about 3.4 to about 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.29 and 0.25.
9. The aluminum-zirconium tetrachlorohydrate of claim 2 , 3 , 4 , 5 , or 6 made with a zirconium hydroxychloride of the formula Zr(OH) 4−b Cl b wherein b is about 3.4 to about 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.29 and 0.25.
10. The aluminum-zirconium tetrachlorohydrate of claim 1 , 2 , 3 , 4 , 5 , 6 or 8 in solid powder form.
11. An aqueous composition comprising water and, dissolved therein, an aluminum-zirconium tetrachlorohydrate according to claim 1 , 2 , 4 , 6 or 8 .
12. The aqueous composition of claim 11 comprising about 8% to about 45% (USP) of said aluminum-zirconium tetrachlorohydrate.
13. A composition comprising a liquid polyhydric alcohol and, dissolved therein, an aluminum-zirconium tetrachlorohydrate according to claim 1 , 2 , 4 , 6 or 8 .
14. The composition of claim 13 comprising about 8% to about 45% (USP) of said aluminum-zirconium tetrachlorohydrate.
15. A clear antiperspirant gel composition comprising a water-in-oil emulsion having a water phase and an oil phase, wherein the water phase comprises an aqueous composition according to claim 12 .
16. A topical antiperspirant composition comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of an aluminum-zirconium tetrachlorohydrate according to claim 1 , 2 , 4 , 6 or 8 .
17. The topical antiperspirant composition of claim 16 wherein said carrier is an anhydrous carrier and said aluminum-zirconium tetrachlorohydrate is in solid powder form suspended in said anhydrous carrier.
18. The topical antiperspirant composition of claim 17 wherein said anhydrous carrier comprises a silicone.
19. The topical antiperspirant composition of claim 16 in the form of a liquid, lotion, cream, gel, soft-solid, or solid stick.
20. A method of reducing perspiration from human skin comprising applying to human skin a topical antiperspirant composition according to claim 16 .
21. A method of reducing perspiration from human skin comprising applying to human skin an aluminum-zirconium tetrachlorohydrate according to claim 1 , 2 , 4 , 6 or 8 .