N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
View Patent ↗Compounds of Formula (I) are effective in the treatment of a microbial infection.
1. A compound of formula (I)
wherein:
a) R 1 is aryl optionally substituted with one or more hydrogen, halo, cyano, hydroxy, carboxy, keto, thioketo, amino, acylamino, acyl, amido, phenyl, aryloxy alkyl, alkenyl, alkynyl, heteroalkyl, halo, haloalkyl, alkoxy, aryl, cycloalkyl, spirocycloalkyl and combinations thereof;
b) each R 2 is independencly chosen from hydrogen, halo, cyano, hydroxy, carboxy, keto, thioketo, amino, acylamino, acyl, amido, phenyl, aryloxy, alkyl, alkenyl, alkynyl, heteroalkyl, halo, haloalkyl, alkoxy, aryl, and cycloalkyl;
c) R 3 and R 4 are each independently chosen from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, aryl, cycloalky, alkylheteroalkyl, alkylaryl, and alkylcycloalkyl; and
d) R 5 and R 6 are each independently chosen from of hydrogen, halo, cyano, hydroxy, carboxy, keto, thioketo, amino, acylamino, acyl, amido, phenyl, aryloxy, alkyl, alkenyl, alkynyl, heteroalkyl, halo, haloatkyl, alkoxy, aryl, and cycloalkyl; or
e) optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, thereof.
2. The compound of claim 1 , wherein R 1 is substituted or unsubstituted phenyl.
3. The compound of claim 2 , wherein R 2 is hydrogen.
4. The compound of claim 3 , wherein R 4 and R 5 are hydrogen.
5. The compound of claim 1 , chosen from:
3-Hydroxy-4-[(2-methoxyethylamino)methyl]-1-(toluene-4-sulfonyl)-1H-pyridin-2-one;
4-(Benzylaminomethyl)-3-hydroxy-1-(toluene-4-sulfonyl)-1H-pyridin-2-one.
6. A method of treating a microbial infection comprising administering a safe and effective of amount of a compound according to claim 1 in a subject in need thereof.
7. A pharmaceutical composition comprising:
a. a safe and effective of amount of a compound according to claim 1
b. a pharmaceutically-acceptable excipient.