IP Library › Granted Patent US 7,094,782
Granted Patent B1
US 7,094,782 · App. 10/703,235 · Granted Aug 22, 2006

Azolo triazines and pyrimidines

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Quick Facts
Patent No.
US 7,094,782
App. No.
10/703,235
Granted
Aug 22, 2006
Kind
B1
Abstract

Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

Claims (6)

1. A method of treating supranuclear palsy in mammals comprising administering to the mammal a therapeutically effective amount of a compound of Formula (2):

and isomers thereof, stereoisomeric forms thereof, or mixtures of stereoisomeric forms thereof, and pharmaceutically acceptable salt forms thereof, wherein:

Ar is 2,3-dihydrobenzofuranyl;

R 1 is CN;

R 1 is H; and

R 14 is C 3 –C 10 alkynyl.