IP Library Granted Patent US 8,932,363
Granted Patent B2
US 8,932,363 · App. 10/704,208 · Granted Jan 13, 2015

Methods for determining meniscal size and shape and for devising treatment

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Quick Facts
Patent No.
US 8,932,363
App. No.
10/704,208
Granted
Jan 13, 2015
Kind
B2
Abstract

The present invention relates to methods for determining meniscal size and shape for use in designing therapies for the treatment of various joint diseases. The invention uses an image of a joint that is processed for analysis. Analysis can include, for example, generating a thickness map, a cartilage curve, or a point cloud. This information is used to determine the extent of the cartilage defect or damage and to design an appropriate therapy, including, for example, an implant. Adjustments to the designed therapy are made to account for the materials used.

Claims (50)

1. A method of selecting an implant having an inner surface for attachment to a bone of a patient's knee joint and an outer surface for providing an articular surface, the method comprising:

obtaining electronic image data of the knee joint;

generating a three dimensional representation of the knee joint;

deriving, from the three dimensional representation, a shape of articular tissue including cartilage of the knee joint;

determining one or more dimensions of a femoral condyle of the knee joint based on the three dimensional representation;

selecting the implant from a library of implants based on the one or more dimensions of the femoral condyle; and

adjusting one or more dimensions of the selected implant to achieve an optimal fit with the patient's knee joint.

2. The method of claim 1 , further including determining one or more dimensions of a tibial plateau of the knee joint based on the three-dimensional representation.

3. The method of claim 2 , wherein the one or more dimensions of a tibial plateau are selected from the group consisting of an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau, a medio-lateral width of the medial tibial plateau, a medio-lateral width of the lateral tibial plateau, and a distance from the tibial spine to an edge of the tibial plateau.

4. The method of claim 2 , wherein the one or more dimensions of a tibial plateau are selected from the group consisting of an anterior-posterior length of the tibial plateau and a medio-lateral width of the tibial plateau.

5. The method of claim 2 , wherein the one or more dimensions of a tibial plateau are selected from an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau and a medio-lateral width of the tibial plateau.

6. The method of claim 1 , including determining one or more dimensions of a medial condyle of the knee joint.

7. The method of claim 1 , including determining one or more dimensions of a lateral condyle of the knee joint.

8. The method of claim 1 , wherein the one or more dimensions of a femoral condyle are selected from the group consisting of an antero-posterior length of the medial femoral condyle, an antero-posterior length of the lateral femoral condyle, a medio-lateral width of the medial femoral condyle, a medio-lateral width of the lateral femoral condyle, an anterior-posterior distance of the femur, a superior-inferior distance of the femur, a medio-lateral distance of the femur, a distance from the trochlea to an edge of the femur; and a width of the intercondylar notch.

9. The method of claim 1 , wherein the one or more dimensions of a femoral condyle include at least two or more medio-lateral widths of a medial and/or a lateral femoral condyle.

10. The method of claim 1 , wherein the one or more dimensions of a femoral condyle include at least two or more composite medio-lateral widths of the joint from a medial to a lateral femoral condyle.

11. The method of claim 1 , further comprising:

deriving, from the three dimensional representation, a shape of articular tissue surrounding or adjacent articular tissue of the knee joint, wherein determining the one or more dimensions of a femoral condyle is further based, at least in part, on the derived shape of the surrounding or adjacent articular tissue.

12. The method of claim 11 , further comprising determining one or more dimensions of a tibial plateau of the knee joint.

13. The method of claim 12 , wherein the one or more dimensions of a tibial plateau is selected from the group consisting of an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau, a medio-lateral width of the medial tibial plateau, a medio-lateral width of the lateral tibial plateau, and a distance from the tibial spine to an edge of the tibial plateau.

14. The method of claim 12 , wherein the one or more dimensions of a tibial plateau include an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau and a medio-lateral width of the tibial plateau.

15. The method of claim 1 , further comprising:

deriving, from the three dimensional representation, a shape of articular tissue surrounding or adjacent diseased articular cartilage of the knee joint, wherein determining the one or more dimensions of a femoral condyle is derived, at least in part, based on subchondral bone underlying the cartilage or surrounding or adjacent articular tissue.

16. The method of claim 1 , wherein the image data is obtained by one or more imaging techniques selected from the group consisting of MRI, CT, laser, ultrasound, digital tomosynthesis, optical coherence tomography, optical imaging and combinations thereof.

17. The method of claim 1 , wherein the image data is obtained non-invasively.

18. A method of selecting an implant having an inner surface for attachment to a bone of a patient's knee joint and an outer surface for providing an articular surface, the method comprising:

obtaining electronic image data of the knee joint;

generating a three dimensional representation of the knee joint;

deriving, from the electronic image data, a shape of articular tissue including cartilage of the knee joint;

determining, based at least in part on the three dimensional representation, one or more medio-lateral dimensions of a femoral condyle of the knee joint;

selecting the implant from a library of implants based on the one or more medio-lateral dimensions of the femoral condyle; and

adjusting one or more dimensions of the selected implant to achieve an optimal fit with the patient's knee joint.

19. The method of claim 18 , wherein the one or more medio-lateral dimensions of a femoral condyle include at least two or more medio-lateral widths of a medial and/or a lateral femoral condyle.

20. The method of claim 18 , wherein the one or more dimensions of a femoral condyle include at least two or more composite medio-lateral widths of the joint from a medial to a lateral femoral condyle.

21. The method of claim 18 , further including determining one or more dimensions of a femoral condyle selected from the group consisting of an antero-posterior length of the medial femoral condyle, an antero-posterior length of the lateral femoral condyle, a medio-lateral width of the medial femoral condyle, a medio-lateral width of the lateral femoral condyle, an anterior-posterior distance of the femur, a superior-inferior distance of the femur, a medio-lateral distance of the femur, a distance from the trochlea to an edge of the femur; and a width of the intercondylar notch.

22. A method of selecting a tibial implant having an inner surface for attachment to a bone of a patient's knee joint and an outer surface for providing an articular surface, the method comprising:

obtaining electronic image data of the knee joint;

generating a three dimensional representation of the knee joint;

deriving, from the three dimensional representation, a shape of articular tissue including cartilage of the knee joint;

determining one or more dimensions of a tibial plateau of the knee joint based on the three-dimensional representation;

selecting the implant from a library of implants based on the one or more dimensions of the tibial plateau; and

adjusting one or more dimensions of the selected implant to achieve an optimal fit with the patient's knee joint.

23. The method of claim 22 , further comprising determining one or more dimensions of a femoral condyle of the knee joint based on the three dimensional representation.

24. The method of claim 23 , wherein the one or more dimensions of a femoral condyle include one or more medio-lateral dimensions of a medial and/or a lateral condyle.

25. The method of claim 23 , wherein the one or more dimensions of a femoral condyle include at least two or more medio-lateral widths of a medial and/or a lateral femoral condyle.

26. The method of claim 23 , wherein the one or more dimensions of a femoral condyle include at least two or more composite mediolateral widths of the joint from a medial to a lateral femoral condyle.

27. The method of claim 22 , comprising determining one or more dimensions of a medial and/or a lateral condyle of the knee joint based on the three dimensional representation.

28. The method of claim 27 , wherein the one or more dimensions of a femoral condyle is selected from the group consisting of an antero-posterior length of the medial femoral condyle, an antero-posterior length of the lateral femoral condyle, a medio-lateral width of the medial femoral condyle, a medio-lateral width of the lateral femoral condyle, an anterior-posterior distance of the femur, a superior-inferior distance of the femur, a medio-lateral distance of the femur, a distance from the trochlea to an edge of the femur; and a width of the intercondylar notch.

29. The method of claim 22 , wherein the one or more dimensions of a tibial plateau include an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau and a medio-lateral width of the tibial plateau.

30. The method of claim 22 , wherein the one or more dimensions of a tibial plateau is selected from the group consisting of an anterior-posterior length of the medial tibial plateau, an anterior-posterior length of the lateral tibial plateau, a medio-lateral width of the medial tibial plateau, a medio-lateral width of the lateral tibial plateau, and a distance from the tibial spine to an edge of the tibial plateau.

Assignments (19)
SECURITY INTEREST Recorded Jun 7, 2024
From: RESTOR3D, INC.; CONFORMIS, INC.; IMATX, INC.
To: TRINITY CAPITAL INC., AS ADMINISTRATIVE AGENT
Reel/Frame 067679/0713 →
RELEASE OF SECURITY INTEREST Recorded Sep 6, 2023
From: MIDCAP FINANCIAL TRUST, AS AGENT FOR LENDERS
To: CONFORMIS, INC.; IMATX, INC.
Reel/Frame 064818/0713 →
RELEASE OF SECURITY INTEREST Recorded Nov 23, 2021
From: CONFORMIS, INC.; IMATX, INC.; CONFORMIS CARES LLC
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 058234/0292 →
SECURITY INTEREST Recorded Nov 22, 2021
From: CONFORMIS, INC.; IMATX, INC.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 058219/0346 →
RELEASE OF SECURITY INTEREST Recorded Sep 12, 2019
From: VENTURE LENDING & LEASING V, INC.
To: CONFORMIS, INC.
Reel/Frame 051897/0504 →
RELEASE OF SECURITY INTEREST Recorded Jun 26, 2019
From: OXFORD FINANCE LLC, AS COLLATERAL AGENT
To: CONFORMIS, INC.
Reel/Frame 049599/0084 →
SECURITY INTEREST Recorded Jun 25, 2019
From: CONFORMIS, INC.; IMATX, INC.; CONFORMIS CARES LLC
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 049588/0288 →
SECURITY INTEREST Recorded Jul 31, 2018
From: CONFORMIS, INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 046676/0152 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT SERIAL NUMBER 13/013466 PREVIOUSLY RECORDED AT REEL: 033460 FRAME: 0396. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY INTEREST. Recorded Oct 20, 2016
From: VENTURE LENDING & LEASING V, INC.; VENTURE LENDING & LEASING VI, INC.
To: CONFORMIS, INC.
Reel/Frame 040424/0437 →
RELEASE OF SECURITY INTEREST Recorded Aug 1, 2014
From: VENTURE LENDING & LEASING V, INC. & VENTURE LENDING & LEASING VI, INC.
To: CONFORMIS, INC.
Reel/Frame 033460/0396 →
RELEASE OF SECURITY INTEREST Recorded Jul 31, 2014
From: VENTURE LENDING & LEASING V, INC.
To: CONFORMIS, INC.
Reel/Frame 033453/0153 →
SECURITY AGREEMENT Recorded Feb 23, 2011
From: CONFORMIS, INC.
To: VENTURE LENDING & LEASING VI, INC.; VENTURE LENDING & LEASING V, INC.
Reel/Frame 025833/0753 →
RELEASE OF SECURITY INTEREST Recorded Aug 25, 2009
From: GE BUSINESS FINANCIAL SERVICES INC. (FORMERLY KNOWN AS MERRILL LYNCH BUSINESS FINANCIAL SERVICES INC.)
To: CONFORMIS, INC.
Reel/Frame 023147/0541 →
SECURITY AGREEMENT Recorded Aug 20, 2009
From: CONFORMIS, INC.
To: VENTURE LENDING & LEASING V, INC.
Reel/Frame 023133/0872 →
SECURITY AGREEMENT Recorded Aug 7, 2007
From: CONFIRMIS, INC.
To: MERRILL LYNCH CAPITAL, A DIVISION OF MERRILL LYNCH BUSINESS FINANCIAL SERVICES INC.
Reel/Frame 019660/0881 →
CORRECTIVE ASSIGNMENT TO CORRECT THE STATE IN THE CHANGE OF ADDRESS OF THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 018482 FRAME 0476. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT ADDRESS OF THE ASSIGNEE IS IN THE STATE OF CALIFORNIA (NOT IN THE STATE OF MASSACHUSETTS). Recorded Jan 24, 2007
From: CONFORMIS, INC.
To: CONFORMIS, INC.
Reel/Frame 018794/0834 →
CHANGE OF ADDRESS OF ASSIGNEE Recorded Nov 3, 2006
From: CONFORMIS, INC.
To: CONFORMIS, INC.
Reel/Frame 018482/0476 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 23, 2004
From: IMAGING THERAPEUTICS, INC.
To: CONFORMIS, INC.
Reel/Frame 014893/0647 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2004
From: TSOUGARAKIS, KONSTANTINOS; STEINES, DANIEL; VISSA, BHASKAR RAO; LANG, PHILIPP; LINDER, BARRY J.
To: IMAGING THERAPEUTICS, INC.
Reel/Frame 014807/0597 →