Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods
View Patent ↗An interstitial brachytherapy apparatus and method for delivering and monitoring radioactive emissions delivered to tissue surrounding a resected tissue cavity. The brachytherapy device including a catheter body member having a proximal end, a distal end, and an outer spatial volume disposed proximate to the distal end of the body member. A radiation source is disposed in the outer spatial volume and a treatment feedback sensor is provided on the device. In use, the treatment feedback sensor can measure the radiation dose delivered from the radiation source.
1. A brachytherapy apparatus for delivering and monitoring radioactive emissions to an internal body location, comprising:
a catheter body member having a proximal end, a distal end, and an outer spatial volume disposed proximate to the distal end of the body member;
a radiation source disposed in the outer spatial volume;
a radiation sensor provided on the device; and
an additional radiation sensor is positioned outside the brachytherapy device;
wherein the radiation sensors measures the radiation delivered from the radiation source.
2. The apparatus of claim 1 , wherein the radiation sensor provided on the device is positioned within the catheter body member.
3. The apparatus of claim 2 , wherein the radiation sensor is positioned in the center of the outer spatial volume.
4. The apparatus of claim 1 , wherein the radiation sensor provided on the device is positioned within the outer spatial volume.
5. The apparatus of claim 1 , wherein the outer spatial volume is defined by an expandable surface member and the radiation sensor provided on the device is mated with the expandable surface.
6. The apparatus of claim 1 , wherein the outer spatial volume is defined by an expandable surface member.
7. The apparatus of claim 6 , wherein the radiation source generates a three-dimensional isodose profile that is substantially similar in shape to the expandable surface member.
8. The apparatus of claim 7 , wherein output from the sensors is used to verify that a three-dimensional isodose profile substantially similar in shape to the expandable surface member is delivered to adjacent tissue.
9. The apparatus of claim 7 , wherein the radiation sensor provided on the device is mated with the expandable surface member.
10. The apparatus of claim 1 , wherein the brachytherapy device generates an asymmetric isodose radiation profile.
11. The apparatus of claim 1 , wherein an inner spatial volume is disposed within the outer spatial volume.
12. The apparatus of claim 11 , wherein the radiation source is disposed within the inner spatial volume.
13. The apparatus of claim 12 , wherein the inner and outer spatial volumes are defined by inner and outer balloons.
14. The apparatus of claim 13 , wherein at least one radiation sensor is positioned on the inner and the outer balloon.
15. The apparatus of claim 1 , wherein the radiation source is a solid radiation source.
16. The apparatus of claim 15 , wherein the radiation sensor provided on the device is positioned on the catheter body member at a position in the longitudinal direction where it is desired to position the radiation source.
17. The apparatus of claim 1 , wherein the brachytherapy apparatus is an interstitial brachytherapy apparatus.
18. The apparatus of claim 1 , wherein more than two radiation sensors are provided.
19. The apparatus of claim 18 , wherein the additional radiation sensor is configured to be positioned in tissue adjacent to the device.
20. The apparatus of claim 18 , wherein the additional radiation sensor is configured to be positioned on the wall of the resected tissue cavity.
21. A brachytherapy apparatus for delivering radioactive emissions to an internal body location, comprising:
a catheter body member having a proximal end, a distal end, and an outer spatial volume disposed proximate to the distal end of the body member;
a radiation source disposed in the outer spatial volume;
a treatment feedback sensor provided on the device; and
an additional treatment feedback sensor is positioned outside the brachytherapy apparatus;
wherein the treatment feedback sensors can be used to evaluate the treatment of proliferative tissue disorders.
22. The apparatus of claim 21 , wherein the treatment feedback sensors measures the radiation delivered from the radiation source.
23. The apparatus of claim 22 , wherein the treatment feedback sensors detects the delivery of a supplemental treatment.
24. The apparatus of claim 23 , wherein the treatment feedback sensors monitors the delivery of a treatment agent to the surrounding tissue.
25. The apparatus of claim 22 , wherein the treatment feedback sensors measures one of the characteristics selected from the group consisting of, tissue temperature, oxygenation, pH, treatment agent concentration, and cytokine concentration.
26. The apparatus of claim 25 , wherein the outer spatial volume is defined by a permeable balloon and the treatment feedback sensors detects a treatment agent which is capable of permeating through the wall of the permeable balloon.
27. The apparatus of claim 22 , wherein the outer spatial volume is defined by an expandable surface member and the treatment feedback sensors are mated with the expandable surface.
28. The apparatus of claim 22 , wherein the treatment feedback sensors are positioned within the catheter body member.