IP Library › Granted Patent US 7,550,423
Granted Patent B2
US 7,550,423 · App. 10/712,081 · Granted Jun 23, 2009

Somatostatin antagonists

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Quick Facts
Patent No.
US 7,550,423
App. No.
10/712,081
Granted
Jun 23, 2009
Kind
B2
Abstract

The invention features somatostatin antagonists having a D-amino acid at the second residue.

Claims (10)

1. A compound of the formula:

H 2 -β-Nal-D-Cys-Tyr-D-Trp-Lys-Val-Cys-(2R,3R-(2-hydroxymethyl)-3-hydroxy)propylamide;

H 2 -Phe-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH 2 ;

H 2 -β-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH 2 ;

H 2 -β-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β-Nal-NH 2 ;

H 2 -β-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH 2 ;

H 2 -D-β-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH 2 ;

H 2 -D-β-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β-Nal-NH 2 ;or

H 2 -Phe-D-Phe-Tyr-D-Trp-Lys-Thr-Phe-Thr-NH 2 ;

or a pharmaceutically acceptable salt thereof.

Assignments (7)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR NAME PREVIOUSLY RECORDED ON REEL 296336 FRAME 0777. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jan 5, 2016
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
To: IPSEN PHARMA S.A.S.
Reel/Frame 037430/0194 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ADDRESS PREVIOUSLY RECORDED ON REEL 023034 FRAME 0251. ASSIGNOR(S) HEREBY CONFIRMS THE ADDRESS SHOULD BE 65 QUAI GEORGES GORSE, 92100 BOULOGNE-BILLANCOURT, FRANCE. Recorded Jan 16, 2013
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S.)
To: IPSEN PHARMA S.A.S.
Reel/Frame 029636/0777 →
CHANGE OF NAME Recorded Jul 31, 2009
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION SCIENTIFIQUES (S.C.R.A.S.)
To: IPSEN PHARMA S.A.S.
Reel/Frame 023034/0251 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE ADDRESS PREVIOUSLY RECORDED AT REEL 015285 FRAME 0217. Recorded Sep 20, 2005
From: BIOMEASURE, INCORPORATED
To: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S.
Reel/Frame 016828/0317 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2004
From: COY, DAVID H.; MURPHY, WILLIAM A.
To: ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE
Reel/Frame 015285/0142 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2004
From: MORGAN, BARRY A.
To: BIOMEASURE, INCORPORATED
Reel/Frame 015285/0201 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2004
From: BIOMEASURE INCORPORATED
To: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S
Reel/Frame 015285/0217 →