Quinolinyl and benzothiazolyl modulators
View Patent ↗Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
1. A compound having the formula:
wherein
A is Cl or CF 3 ;
C is Cl or CF 3 ;
D is H or CH 3 ;
V is F or Cl;
X is a member selected from the group consisting of H, CH 3 , COOH, and CO 2 CH 3 ; and
Y is a member selected from the group consisting of H, CO 2 H and CO 2 CH 3 ;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein V is Cl.
3. The compound of claim 1 , wherein X and Y are each H.
4. The compound of claim 1 , wherein A is Cl.
5. The compound of claim 1 , wherein A is CF 3 .
6. The compound of claim 1 , wherein D is H.
7. The compound of claim 1 , wherein A is Cl and D is H.
8. The compound of claim 1 , wherein A is Cl; C is Cl; and V is Cl.
9. The compound of claim 1 , wherein C is CF 3 .
10. The compound of claim 1 , wherein A is Cl; C is Cl; V is Cl, D is CH 3 , and X and Y are each H.
11. The compound of claim 1 , wherein A is Cl; C is Cl; V is Cl, D is H, and X and Y are each H.
12. A composition comprising a pharmaceutically acceptable carrier or excipient and a compound having the formula:
wherein
A is Cl or CF 3 ;
C is Cl or CF 3 ;
D is H or CR 3 ;
V is F or Cl;
X is a member selected from the group consisting of H, CH 3 , COOH, and CO 2 CH 3 ; and
Y is a member selected from the group consisting of H, CO 2 H and CO 2 CH 3 ;
or a pharmaceutically acceptable salt thereof.
13. The composition of claim 12 , wherein V is Cl.
14. The composition of claim 12 , wherein X and Y are each H.
15. The composition of claim 12 , wherein A is Cl.
16. The composition of claim 12 , wherein A is CF 3 .
17. The composition of claim 12 , wherein D is H.
18. The composition of claim 12 , wherein A is Cl and D is H.
19. The composition of claim 12 , wherein A is Cl; C is Cl; and V is Cl.
20. The composition of claim 12 , wherein C is CF 3 .
21. The composition of claim 12 , wherein A is Cl; C is Cl; V is Cl, D is CH 3 , and X and Y are each H.
22. The composition of claim 12 , wherein A is Cl; C is Cl; V is Cl, D is H, and X and Y are each H.