Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.
1. A vaccine for the protection of poultry against Eimeria infection, comprising
the hydrophulic polypeptide SEQ ID No:3
and a pharmaceutically acceptable carrier.
2. The vaccine according to claim 1 , which additionally comprises an adjuvant.
3. The vaccine according to claim 1 , which comprises at least one additional immunogen of a poultry pathogen.
4. The vaccine according to claim 3 , wherein the at least one poultry pathogen is selected from the group consisting of Marek's Disease virus (MDV), Newcastle Disease virus (MDV), Infectious Bronchitis virus (IBV), Chicken Anaemia Agent (CAA), Reovirus, Avian Retrovirus, Fowl Adenovirus, Turkey Rhinotracheitis virus, Salmonella spp. and E. coli.
5. The vaccine according to claim 1 which is in freeze-dried form.