IP Library › Granted Patent US 7,943,593
Granted Patent B2
US 7,943,593 · App. 10/728,114 · Granted May 17, 2011

Compositions comprising inhibitors of IMPDH enzyme

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Quick Facts
Patent No.
US 7,943,593
App. No.
10/728,114
Granted
May 17, 2011
Kind
B2
Abstract

The present invention relates to compositions comprising an apoptosis inducing anti-cancer agent and an IMPDH inhibitor. This invention also relates to methods for inducing apoptosis and for treating tumors and cancers in mammals.

Claims (6)

1. A composition comprising:

(a) fludarabine;

(b) compound 181:

wherein each of said fludarabine and said compound 181 are independently present in a therapeutically effective amount; and

(c) a pharmaceutically acceptable carrier.

2. A method for treating lymphoma, leukemia, myelodysplastic syndrome, metastatic melanoma breast cancer, colon cancer, pancreatic cancer, and prostate cancer in a mammal comprising the step of administrating to said mammal a composition according to claim 1 .

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
SECURITY AGREEMENT Recorded Oct 28, 2008
From: AVALON PHARMACEUTICALS, INC.
To: CLINICAL DATA, INC.
Reel/Frame 021744/0652 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 1, 2004
From: JAIN-PANDEY, JUGNU; FRAM, ROBERT J.
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 015099/0847 →