IP Library › Granted Patent US 6,936,621
Granted Patent B2
US 6,936,621 · App. 10/729,313 · Granted Aug 30, 2005

Use of benzoylalkyl-1,2,3,6-tetrahydropyridines

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Quick Facts
Patent No.
US 6,936,621
App. No.
10/729,313
Granted
Aug 30, 2005
Kind
B2
Abstract

The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.

Claims (19)

1. A compound of formula (I′)

in which

R′ 1 is halogen, a CF 3 , (C 1 -C 4 ) alkyl or (C 1 -C 4 ) alkoxy group;

R′ 2 is phenyl, phenoxy, phenylmethyl or phenylethyl, said groups optionally mono- or polysubstituted on the phenyl group by halogen, CF 3 , (C 1 -C 4 ) alkyl or (C 1 -C 4 ) alkoxy;

R′ 3 is hydrogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, halogen, a CF 3 group or hydroxy;

or a salt or quaternary ammonium salt thereof.

2. A compound according to claim 1 selected from the group consisting of:

1-{2-(3′-chlorobiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(2′-chlorobiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(4′-chlorobiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(4-benzylphenyl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(4′-fluorobiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(biphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(2′-trifluoromethylbiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(3′-trifluoromethylbiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

1-{2-(4′-trifluoromethylbiphenyl-4-yl)-2-oxoethyl}-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydropyridine;

or a pharmaceutically acceptable salt thereof.

3. A pharmaceutical composition comprising a compound according to claim 1 together with a pharmaceutically acceptable vehicle or diluent.

4. A pharmaceutical composition comprising a compound according to claim 2 together with a pharmaceutically acceptable vehicle or diluent.