Cardioprotective phosphonates and malonates
View Patent ↗The present invention provides for pyridoxine phosphonate analogues, pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases.
1. A method of treating myocardial infarction in a mammal comprising administering to the mammal in a unit dosage form a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable acid addition salt thereof.
2. The method of claim 1 , wherein the compound is administered enterally or parenterally.
3. The method of claim 1 , wherein the compound is administered concurrently with a therapeutic cardiovascular compound selected from the group consisting of an angiotensin converting enzyme inhibitor, a calcium channel blocker, a β-adrenergic receptor antagonist, a vasodilator, a diuretic, an α-adrenergic receptor antagonist, and a mixture thereof.
4. A method of treating ischemia reperfusion injury in a mammal comprising administering to the mammal a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable acid addition salt thereof.
5. The method of claim 4 , wherein the compound is administered enterally or parenterally.
6. The method of claim 4 , wherein the compound is administered concurrently with a therapeutic cardiovascular compound selected from the group consisting of an angiotensin converting enzyme inhibitor, an angiotensin II receptor antagonist, a calcium channel blocker, and a mixture thereof.
7. A method of treating myocardial ischemia in a mammal comprising administering to the mammal a therapeutically effective amount of a compound of formula
or a pharmaceutically acceptable acid addition salt thereof.
8. The method of claim 7 , wherein the compound is administered enterally or parenterally.
9. The method of claim 7 , wherein the compound is administered concurrently with a therapeutic cardiovascular compound selected from the group consisting of an angiotensin converting enzyme inhibitor, an angiotensin LI receptor antagonist, a calcium channel blocker, an antithrombolytic agent, a β-adrenergic receptor antagonist, a diuretic, an α-adrenergic receptor antagonist, and a mixture thereof.