Treatment of mastalgia with 4-hydroxy tamoxifen
A method of treatment comprises administering 4-hydroxy tamoxifen percutaneously to a patient having mastalgia. The 4-hydroxy tamoxifen may be formulated in a hydroalcoholic gel or an alcoholic solution.
1. A method of treatment for mastalgia, comprising administering percutaneously to the breasts of a patient having mastalgia a composition comprising 4-hydroxy tamoxifen as the sole therapeutically active ingredient, at a dose of at least 1.5 mg/day 4-hydroxy tamoxifen.
2. A method according to claim 1 , wherein said composition comprises a penetration enhancer.
3. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is a blend of trans and cis isomers.
4. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is a trans isomer.
5. A method according to claim 1 , wherein greater than about 0.75 mg/breast of said 4-hydroxy tamoxifen is administered to said patient per day.
6. A method according to claim 1 , wherein greater than about 1 mg/breast of said 4-hydroxy tamoxifen is administered to said patient per day.
7. A method according to claim 1 , wherein said composition is a hydroalcoholic gel.
8. A method according to claim 7 , wherein said hydroalcoholic gel comprises ethyl alcohol, isopropyl myristate, and hydroxypropylcellulose.
9. A method according to claim 1 , wherein said composition is an alcoholic solution.
10. A method according to claim 1 , wherein said mastalgia is cyclical.
11. A method according to claim 1 , wherein about 0.75 mg/breast of said 4-hydroxy tamoxifen is administered to said patient per day.
12. A method according to claim 1 , wherein about 1 mg/breast of said 4-hydroxy tamoxifen is administered to said patient per day.
13. A method according to claim 1 , wherein about 2 mg of said 4-hydroxy tamoxifen is administered to said patient per day.