Antibiotic Cyan426-A
View Patent ↗The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
1. A compound having the formula
2. A method of treating a mammal affected by bacterial infections, which method comprises administering to said mammal an effective amount of the compound of claim 1 .
3. A pharmaceutical composition comprising an effective amount of the compound of claim 1 together with a pharmaceutical acceptable carrier.
4. A compound having the formula:
where R is lower alkyl of 1 to 6 carbon atoms.
5. A method of treating a mammal affected by bacterial infections, which method comprises administering to said mammal an effective amount of a compound of claim 4 .
6. A pharmaceutical composition comprising an effective amount of a compound of claim 4 together with a pharmaceutical acceptable carrier.
7. The compound of claim 4 , where R is methyl and having the formula
8. A process for the preparation of compounds of the formula:
which comprises reacting a compound of the formula
with an alcohol ROH where R is lower alkyl of 1 to 6 carbon atoms in the presence of an acid and isolating the compounds having the formula:
9. The compound according to claim 8 where R is CH 3 having the formula
10. The acid according to claim 8 which is hydrogen chloride.