Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B
View Patent ↗The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
1. The compound which has the structure
2. The compound which has the structure
3. The compound which has the structure
4. The compound which has the structure:
wherein R is straight or branched alkyl of 1 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms and cycloalkenyl of 3 to 10 carbon atoms.
5. The compound according to claim 4 where R is —CH 2 CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 CH 3 , or —CH 2 CH 2 CH 2 CH 2 CH 3 .
6. A pharmaceutical composition comprising an effective amount of a compound of claim 1 together with a pharmaceutically acceptable carrier.
7. A pharmaceutical composition comprising an effective amount of a compound of claim 2 together with a pharmaceutically acceptable carrier.
8. A pharmaceutical composition comprising an effective amount of a compound of claim 3 together with a pharmaceutically acceptable carrier.
9. A pharmaceutical composition comprising an effective amount of a compound of claim 4 together with a pharmaceutically acceptable carrier.
10. A pharmaceutical or disinfectant composition which contains an effective antimicrobial, antiseptic or disinfectant amount of the compound of claim 1 as an active ingredient.
11. A pharmaceutical or disinfectant composition which contains an effective antimicrobial, antiseptic or disinfectant amount of a compound of claim 2 as an active ingredient.
12. A pharmaceutical or disinfectant composition which contains an effective antimicrobial, antiseptic or disinfectant amount of a compound of claim 3 as an active ingredient.
13. A pharmaceutical or disinfectant composition which contains an effective antimicrobial, antiseptic or disinfectant amount of a compound of claim 4 as an active ingredient.