IP Library › Granted Patent US 7,169,904
Granted Patent B2
US 7,169,904 · App. 10/737,208 · Granted Jan 30, 2007

Immunocytokine sequences and uses thereof

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Quick Facts
Patent No.
US 7,169,904
App. No.
10/737,208
Granted
Jan 30, 2007
Kind
B2
Abstract

The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.

Claims (5)

1. An antibody variable region comprising the amino acid sequence set forth in SEQ ID NO: 1.

2. An antibody variable region comprising the amino acid sequence set forth in SEQ ID NO: 2.

3. The antibody variable region of claim 2 further comprising the amino acid sequence set forth in SEQ ID NO: 1.

4. The antibody variable region of claim 3 , wherein the amino acid sequences are linked by a disulfide bond.

5. The antibody variable region of claim 3 , wherein the amino acid sequences are linked by a peptide bond.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2009
From: EMD SERONO RESEARCH CENTER, INC.
To: MERCK PATENT GMBH
Reel/Frame 022856/0508 →
CHANGE OF NAME Recorded May 20, 2008
From: EMD LEXIGEN RESEARCH CENTER CORP.
To: EMD SERONO RESEARCH CENTER, INC.
Reel/Frame 020963/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2005
From: QIAN, SUSAN X.
To: EMD LEXIGEN RESEARCH CENTER CORP.
Reel/Frame 017191/0491 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2004
From: GILLIES, STEPHEN D.; LO, KIN-MING
To: EMD LEXIGEN RESEARCH CENTER CORP.
Reel/Frame 015274/0465 →