IP Library › Granted Patent US 7,407,645
Granted Patent B2
US 7,407,645 · App. 10/737,486 · Granted Aug 5, 2008

Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands

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Quick Facts
Patent No.
US 7,407,645
App. No.
10/737,486
Granted
Aug 5, 2008
Kind
B2
Abstract

The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R 1 , R′ 1 , R 2 , R′ 2 , R 3 , R′ 3 , R 4 , R′ 4 , R 5 , R′ 5 , R 6 , R′ 6 , R 7 , R′ 7 , R 8 , R′ 8 , R 9 , R′ 9 , M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.

Claims (6)

1. A compound which is complex represented by the

wherein said biomolecule is independently selected from the group consisting of steroids, carbohydrates, fatty acids, amino acids, peptides, proteins, antibodies, vitamins, lipids, phospholipds, phosphates, phosphonates, nucleic acids, enzyme substrates, enzyme inhibitors and enzyme receptor substrates.

2. Compound of claim 1 wherein the biomolecule is a carbohydrate.

3. Compound of claim 2 wherein the biomolecule is a polysaccharide.

4. Compound of claim 3 wherein the biomolecule is a glycosaminoglycan.

5. Compound of claim 3 wherein the biomolecule is hyaluronic acid.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2012
From: BUCKLER, PHILLIP M.; BEARDSLEY, ROBERT A.
To: GALERA THERAPEUTICS
Reel/Frame 028751/0006 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 8, 2012
From: BUCKLER, PHILLIP M.; BEARDSLEY, ROBERT A.
To: GALERA THERAPEUTICS
Reel/Frame 028751/0084 →