Method for the production of a blood component composition
View Patent ↗A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.
1. A method of producing a blood component composition, comprising:
providing an anticoagulated blood sample having multiple inactive components from a patient;
centrifuging the blood sample to separate said inactive blood components;
combining a first portion of one of the separated inactive blood components with an activation agent to form a clot containing thrombin;
filtering the thrombin from the clot;
combining one or more medicinal materials with a second portion of the separated inactive blood component; and
combining the thrombin and the second portion of the separated inactive blood component comprising the one or more medicinal materials to produce the blood component composition.
2. The method of claim 1 , wherein the first portion of the separated inactive blood component is combined with a restoration agent.
3. The method of claim 2 , wherein the blood sample is anticoagulated with heparin prior to centrifuging.
4. The method of claim 3 , wherein the restoration agent is an anti-heparin agent.
5. The method of claim 4 , wherein the anti-heparin agent is heparinase or protamine.
6. The method of claim 1 , wherein the activation agent is glass wool, silica, aluminum, diatomaceous earth, kaolin, plastic, siliconized glass or a chemical activator.
7. The method of claim 1 , wherein the inactive blood component is inactive platelet rich plasma.
8. The method of claim 1 , wherein the inactive blood component is inactive platelet poor plasma.
9. The method of claim 1 , wherein the one or more medicinal materials are selected from the group consisting of drugs, analgesic compounds, antibacterial compounds, antibiotics, antifungal compounds, anti-inflammatories, antiparasitic compounds, antiviral compounds, anticancer compounds, genetic agents, enzyme inhibitors, glycoproteins, growth factors, hormones, steroids, glucocorticosteroids, immunomodulators, immunoglobulins, minerals, neuroleptics, proteins, peptides, lipoproteins, tumoricidal compounds, tumorstatic compounds, toxins, vitamins, bone, gelatin, collagen, degradable polymers, hyaluronic acid, carbohydrates and starches.
10. The method of claim 1 , further comprising applying the blood component composition to a desired location on or within the patient.
11. The method of claim 10 , wherein the desired location is a wound.
12. The method of claim 1 , wherein the one or more medicinal materials are obtained from the patient.
13. A method of producing a blood component composition, comprising:
providing an anticoagulated blood sample having multiple inactive components from a patient;
centrifuging the blood sample to separate said inactive blood components;
combining a first portion of one of the separated inactive blood components with an activation agent to form a clot containing thrombin;
filtering the thrombin from the clot;
providing a medicinal material obtained from the patient;
combining the medicinal material with a second portion of the separated inactive blood component; and
combining the thrombin and the second portion of the separated inactive blood component comprising the medicinal material to produce the blood component composition.
14. The method of claim 13 , wherein the first portion of the separated inactive blood component is further combined with a restoration agent.
15. The method of claim 14 , wherein the blood sample is anticoagulated with heparin prior to centrifuging.
16. The method of claim 15 , wherein the restoration agent is, an anti-heparin agent.
17. The method of claim 16 , wherein the anti-heparin agent is heparinase or protamine.
18. The method of claim 13 , wherein the activation agent is glass wool, silica, aluminum, diatomaceous earth, kaolin, plastic, siliconized glass or a chemical activator.
19. The method of claim 13 , wherein the inactive blood component is inactive platelet rich plasma.
20. The method of claim 13 , wherein the inactive blood component is inactive platelet poor plasma.
21. The method of claim 13 , wherein the medicinal material is selected from the group consisting of genetic agents, growth factors, hormones, steroids, proteins, peptides, vitamins, bone, gelatin and collagen.
22. The method of claim 13 , further comprising applying the blood component composition to a desired location on or within the patient.
23. The method of claim 22 , wherein the desired location is a wound.