Methods of modulating IFNy production
View Patent ↗Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
1. A method of inhibiting IFNγ production from a cell, comprising contacting the cell with an effective amount of a first antibody or antibody fragment thereof that antagonizes IL-27 activity in conjunction with an effective amount of a second antibody or antibody fragment that inhibits activity of IL-12.
2. The method of claim 1 wherein the cell is a human cell selected from the group consisting of an NK cell and a T cell.
3. The method of claim 1 , wherein the first antibody or antibody fragment thereof binds to a polypeptide selected from the group consisting of p28, EBI3, a complex of p28 and EBI3, and WSX-1/TCCR.
4. The method of claim 3 , wherein the first antibody or antibody fragment thereof binds the polypeptide with a K D of at least 10 −3 M.
5. The method of claim 3 , wherein the first antibody or antibody fragment thereof binds the polypeptide with a K D of at least 10 −6 M.
6. The method of claim 3 , wherein the first antibody or antibody fragment thereof binds the polypeptide with a K D of at least 10 −11 M.
7. The method of claim 1 wherein the first and second antibody or antibody fragment thereof are humanized or chimeric.