Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation
View Patent ↗Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art.
1. A porous inorganic/organic hybrid material, comprising porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, wherein said particles have been surface modified with a surface modifier having the formula Z a (R′) b Si—R, where Z=Cl, Br, I, C 1 –C 5 alkoxy, dialkylamino or trifluoromethanesulfonate; a and b are each an integer from 0 to 3 provided that a+b=3; R′ is a C 1 –C 6 straight, cyclic or branched alkyl group, and R is a functionalizing group.
2. The hybrid material-of claim 1 , wherein said particles have been further surface modified by coating with a polymer.
3. The hybrid material of claim 1 wherein R′ is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, t-butyl, sec-butyl, pentyl, isopentyl, hexyl and cyclohexyl.
4. The hybrid material of claim 1 wherein the functionalizing group R is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cyano, amino, diol, nitro, ester, a cation or anion exchange group, and an alkyl or aryl group containing an embedded polar functionality.
5. The hybrid material of claim 4 , wherein said functionalizing group R is a C 1 –C 30 alkyl group.
6. The hybrid material of claim 4 , wherein said functionalizing group R is a C 1 –C 20 alkyl group.
7. The hybrid material of claim 1 , wherein said surface modifier is selected from the group consisting of octyltrichlorosilane, octadecyltrichlorosilane, octyldimethylchlorosilane, and octadecyldimethylchlorosilane.
8. The hybrid material of claim 7 , wherein said surface modifier is selected from the group consisting of octyltrichlorosilane and octadecyltrichlorosilane.
9. The hybrid material of claim 1 , wherein said particles have been surface modified by a combination of organic group and silanol group modification.
10. The hybrid material of claim 1 , wherein said particles have been surface modified by a combination of organic group modification and coating with a polymer.
11. The hybrid material of claim 1 , wherein said particles have been surface modified by a combination of silanol group modification and coating with a polymer.
12. The hybrid material of claim 1 , wherein said particles have been surface modified via formation of an organic covalent bond between the particle's organic group and the modifying reagent.
13. The hybrid material of claim 1 , wherein said particles have been surface modified by a combination of organic group modification, silanol group modification, and coating with a polymer.
14. The hybrid material of claim 1 , wherein said particles have been surface modified by silanol group modification.
15. A separations device having a stationary phase comprising porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, wherein the particles have been surface modified with a surface modifier having the formula Z a (R′) b Si—R, where Z=Cl, Br, I, C 1 –C 5 alkoxy, dialkylamino or trifluoromethanesulfonate; a and b are each an integer from 0 to 3 provided that a+b=3; R′ is a C 1 –C 6 straight, cyclic or branched alkyl group, and R is a functionalizing group.
16. The separations device of claim 15 , wherein said surface modifier is selected from the group consisting of octyltrichlorosilane, octadecyltrichlorosilane, octyldimethylchlorosilane, and octadecyldimethylchlorosilane.
17. The separations device of claim 16 , wherein said surface modifier is selected from the group consisting of octyltrichlorosilane and octadecyltrichlorosilane.
18. The separations device of claim 15 , wherein said functionalizing group R is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cyano, amino, diol, nitro, ester, a cation or anion exchange group, and an alkyl or aryl group containing an embedded polar functionality.
19. The separations device of claim 15 , wherein said functionalizing group R is a C 1 –C 30 alkyl group.
20. A chromatographic column having improved lifetime, comprising
a) column having a cylindrical interior for accepting a packing material, and
b) a packed chromatographic bed comprising porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry that have been surface modified with a surface modifier having the formula Z a (R′) b Si—R, where Z=Cl, Br, I, C 1 –C 5 alkoxy, dialkylamino or trifluoromethanesulfonate; a and b are each an integer from 0 to 3 provided that a+b=3; R′ is a C 1 –C 6 straight, cyclic or branched alkyl group, and R is a functionalizing group.
21. A chromatographic column having improved lifetime, comprising
a) column having a cylindrical interior for accepting a packing material, and
b) a packed chromatographic bed comprising porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry that have been surface modified with a surface modifier having the formula Z a (R′) b Si-R, where Z=Cl, Br, I, C 1 –C 5 alkoxy, dialkylamino or trifluoromethanesulfonate; a and b are each an integer from 0 to 3 provided that a+b=3; R′ is a C 1–C 6 straight, cyclic or branched alkyl group, and R is a functionalizing group.