Anti-cancer medicaments

1. A compound of the formula

wherein:

R 1 is selected from the group consisting of:

and W is CH thereof; each R 2 is individually selected from the group consisting of —H, alkyls, aminos, alkylaminos, arylaminos, cycloalkylaminos, halogens, alkoxys and hydroxys;

each X and Y is individually selected from the group consisting of —O—, —S—, —NR 6 —, —NR 6 SO 2 —, —NR 6 CO—, alkynyls, alkenyls, alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, where each h is individually selected from the group consisting of 1, 2, 3, or 4, and where for each of alkylenes, —O(CH 2 ) h —, and —NR 6 (CH 2 ) h —, one of the methylene groups present therein may be optionally double-bonded to a side-chain oxo group except that with —O(CH 2 ) h —, the introduction of the side-chain oxo group does not form an ester moiety;

A is a pyrimidyl;

D is a phenyl;

E is a phenyl;

L is selected from the group consisting of —C(O)—, —S(O) 2 —, —N(R 6 )CO—, —N(R 6 )SO 2 —, —N(R 6 )CON(R 6 )—;

each of m, n, p and q is 1;

j is 0 or 1;

t is 0 or 1;

Q is selected from the group consisting of

each R 4 group is individually selected from the group consisting of —H, alkyls, aminoalkyls, alkoxyalkyls, aryls, aralkyls, except when the R 4 substituent places a heteroatom on an alpha-carbon directly attached to a ring nitrogen on Q;

each R 5 is individually selected from the group consisting of —H, alkyls, aryls, alkylaminos, arylaminos, cycloalkylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arylthios, cyanos, halogens, perfluoroalkyl, alkylcarbonyls, and nitros;

each R 6 is individually selected from the group consisting of —H, alkyls, allyls, and β-trimethylsilylethyl;

each R 8 is individually selected from the group consisting of alkyls, and aralkyls;

each R 9 group is individually selected from the group consisting of —H, —F, and alkyls, wherein when two R 9 groups are geminal alkyl groups, said geminal alkyl groups may be cyclized to form a 3-6 membered ring;

G is selected from the group consisting of —O—, —S—, and —N(R 4 )—;

k is 0 or 1;

each Z is individually selected from the group consisting of —O— and —N(R 4 )—; and

each ring of formula (I) optionally includes one or more of R 7 , where R 7 is a noninterfering substituent individually selected from the group consisting of—H, alkyls, aryls, alkylaminos, arylaminos, cycloalkylaminos, hydroxys, alkoxys, aryloxys, alkylthios, arthylthios, cyanos, halogens, nitros, alkylsulfinyls, alkylsulfonyls, aminosulfonyls, and perfluoroalkyls.

2. The compound of claim 1 , wherein L is —NH—CO—NH— and j is 0.

3. The compound of claim 2 , wherein Q is