Substituted alkyl amido piperidines

1. A compound having the structure:

wherein each R 1 is independently hydrogen; —F; —Cl; —Br; —I; —CN; —NO 2 ; straight chained or branched C 1 –C 7 alkyl, monofluoroalkyl or polyfluoroalkyl; straight chained or branched C 2 –C 7 alkenyl; C 3 –C 7 cycloalkyl or C 5 –C 7 cycloalkenyl; aryl; heteroaryl; —N(R 5 ) 2 ; —(CH 2 ) m OR 5 ; —COR 5 ; —CO 2 R 5 ; —OCOR 5 ; —CON(R 5 ) 2 ; —N(R 5 )COR 5 ; —N(R 5 )CON(R 5 ) 2 ; —OCON(R 5 ) 2 or —N(R 5 )CO 2 R 5 ;

wherein R 2 is hydrogen; —F; —Cl; —Br; —I; —CN; —(CH 2 ) m OR 5 ; —(CH 2 ) m SR 5 ; —NH 2 ; straight chained or branched C 1 –C 7 alkyl, monofluoroalkyl, polyfluoroalkyl; aryl or heteroaryl, wherein the aryl or heteroaryl may be substituted with one or more R 1

wherein R 3 is hydrogen; —F; —Cl; —Br; —I; —CN; —(CH 2 ) m OR 5 ; —(CH 2 ) m SR 5 ; straight chained or branched C 1 –C 7 alkyl, monofluoroalkyl, polyfluoroalkyl; aryl or heteroaryl, wherein the aryl or heteroaryl may be substituted with one or more R 1 ; or wherein R 2 and R 3 together can be —(CH 2 ) p —;

wherein R 4 is straight chained or branched C 1 –C 7 alkyl, monofluoroalkyl or polyfluoroalkyl, C 3 –C 6 cycloalkyl, C 1 –C 7 alkyl-C 3 –C 6 cycloalkyl; —N(R 5 ) 2 or —(CH 2 ) m OR 5 ;

wherein each R 5 is independently hydrogen; aryl; heteroaryl or straight chained or branched C 1 –C 7 alkyl, wherein the alkyl may be substituted with an aryl or heteroaryl;

wherein each R 6 is independently hydrogen; straight chained or branched C 1 –C 7 alkyl;

wherein each R 7 is independently hydrogen; phenyl or straight chained or branched C 1 –C 7 alkyl, wherein the alkyl may be substituted with a phenyl;

wherein each m is independently an integer from 0 to 5 inclusive;

wherein n is an integer from 1 to 5 inclusive;

wherein p is an integer from 2 to 7 inclusive;

wherein q is an integer from 0 to 2 inclusive; and

wherein each X is independently CR 1 or N, provided that if one X is N then the remaining X are CR 1 ;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , where the compound has the structure:

3. The compound of claim 1 , wherein R 7 is independently hydrogen or straight chained or branched C 1 –C 7 alkyl; and R 4 is straight chained or branched C 1 –C 7 alkyl.

4. The compound of claim 1 , wherein each R 1 is independently hydrogen; —F; —Cl; —Br; —I or straight chained or branched C 1 –C 7 alkyl; and R 2 is hydrogen or straight chained or branched C 1 –C 7 alkyl.

5. The compound of claim 4 , wherein n is 2.

6. The compound of claim 1 , wherein the compound is selected from the group consisting of:

7. The compound of claim 1 , wherein R 2 and R 3 are independently hydrogen or straight chained or branched C 1 –C 7 alkyl.

8. The compound of claim 7 , wherein each R 5 is independently hydrogen or straight chained or branched C 1 –C 3 alkyl; R 7 is independently hydrogen or straight chained or branched C 1 –C 7 alkyl; and R 4 is straight chained or branched C 1 –C 7 alkyl.

9. The compound of claim 8 , wherein each R 1 is independently hydrogen; —F; —Cl; —Br; —I or straight chained or branched C 1 –C 7 alkyl.

10. The compound of claim 9 , wherein n is 2.

11. The compound of claim 10 , wherein the compound is selected from the group consisting of:

12. The compound of claim 1 , wherein the compound has the structure:

13. The compound of claim 1 , wherein R 2 and R 3 together are —(CH 2 ) p .

14. The compound of claim 2 , wherein the compound has the structure:

wherein R 2 is hydrogen or —OH.

15. The compound of claim 14 , wherein R 3 is phenyl substituted with one or more R 1 moieties; and q=0.

16. The compound of claim 15 , wherein each R 5 is independently hydrogen or straight chained or branched C 1 –C 3 alkyl, wherein the alkyl may be substituted with a phenyl; R 7 is independently hydrogen or straight chained or branched C 1 –C 7 alkyl; and R 4 is straight chained or branched C 1 –C 7 alkyl.

17. The compound of claim 16 , wherein each R 1 is independently hydrogen; —F; —Cl; —Br; —I or straight chained or branched C 1 –C 7 alkyl.

18. The compound of claim 17 , wherein n is 2.

19. The compound of claim 18 , wherein X is N.

20. The compound of claim 18 , wherein X is CR 1 .

21. The compound of claim 20 , wherein R 2 is OH.

22. The compound of claim 21 , wherein the compound is selected from the group consisting of:

23. The compound of claim 2 , wherein the compound has the structure:

24. The compound of claim 23 , wherein R 3 is phenyl substituted with one or more R 1 moieties; and q=0.

25. The compound of claim 24 , wherein R 5 and R 7 are independently hydrogen or straight chained or branched C 1 –C 7 alkyl; and R 4 is straight chained or branched C 1 –C 7 alkyl.

26. The compound of claim 25 , wherein R 2 is hydrogen or —OH.

27. The compound of claim 26 , wherein the compound has the structure:

28. The compound of claim 1 , wherein the compound is enantiomerically pure.

29. The compound of claim 1 , wherein the compound is diastereomerically pure.

30. A process for making a pharmaceutical composition comprising admixing a compound of claim 1 and a pharmaceutically acceptable carrier.

31. A pharmaceutical composition that comprises a therapeutically effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.

32. A pharmaceutical composition made by admixing a compound of claim 1 and a pharmaceutically acceptable carrier.

33. A method of treating a subject suffering from an affective disorder selected from the group consisting of depression, major depression, and anxiety, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .

34. The method of claim 33 , wherein the affective disorder is depression.

35. A method of treating a subject suffering from a urinary disorder selected from the group consisting of urinary incontinence, urge incontinence, urinary frequency, urinary urgency, nocturia or enuresis comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .

36. A method of treating a subject suffering from obesity, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .